INT258745

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Context Info
Confidence 0.11
First Reported 2006
Last Reported 2008
Negated 2
Speculated 1
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 5.92
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Lmo1) nucleus (Lmo1)
Lmo1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 303 97.92 Very High Very High Very High
depression 19 88.96 High High
Neurotransmitter 100 80.04 Quite High
antagonist 11 75.24 Quite High
dopamine receptor 24 74.40 Quite High
sSRI 19 69.32 Quite High
Serotonin 93 48.88 Quite Low
imagery 18 36.16 Quite Low
positron emission tomography 15 34.84 Quite Low
alcohol 42 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 445 99.80 Very High Very High Very High
Attention Deficit And Disruptive Behavior Disorders 39 99.40 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 912 99.32 Very High Very High Very High
Conduct Disorder 69 99.20 Very High Very High Very High
Depression 22 88.96 High High
Syndrome 89 71.40 Quite High
Affective Disorder 6 70.32 Quite High
Tourette's Syndrome 53 64.16 Quite High
Obsessive-compulsive Disorder 19 50.00 Quite Low
Congenital Anomalies 16 49.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They found a significant association between the DAT1 10 allele and ODD, CD, and hyperactivity-impulsivity.
DAT1 Binding (association) of associated with conduct disorder, attention deficit and disruptive behavior disorders and attention deficit hyperactivity disorder
1) Confidence 0.11 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626918 Disease Relevance 2.09 Pain Relevance 0.06
Cook et al (1995) reported a significant positive association between the 10 allele of the DAT1 gene and 49 cases of ADHD using the haplotype relative risk procedure.
DAT1 gene Binding (association) of associated with attention deficit hyperactivity disorder
2) Confidence 0.08 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626918 Disease Relevance 0.89 Pain Relevance 0.22
Frisch et al.38 reported that there was no association between the DAT1 gene and OCD in Jews, and Hemmings et al.28 also did not find any difference in the distribution of DAT1 VNTR between the OCD and control groups.
DAT1 gene Neg (no) Binding (association) of associated with anxiety disorder
3) Confidence 0.08 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687723 Disease Relevance 0.69 Pain Relevance 0.31
Winsberg and Comings (1999) examined the correlation between response to methylphenidate treatment and DAT1 genotype in a series of 30 African-American children with ADHD.
DAT1 Spec (examined) Binding (genotype) of associated with attention deficit hyperactivity disorder
4) Confidence 0.08 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626918 Disease Relevance 1.49 Pain Relevance 0.06
However, we did not find any significant association between the DAT1 gene and OCD.
DAT1 gene Neg (not) Binding (association) of associated with anxiety disorder
5) Confidence 0.06 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687723 Disease Relevance 0.77 Pain Relevance 0.19

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