INT258759

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 4.71
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 4
ADHD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 4 100.00 Very High Very High Very High
agonist 7 98.32 Very High Very High Very High
antidepressant 3 87.28 High High
drug abuse 16 75.96 Quite High
headache 13 52.00 Quite High
Dopamine 101 47.96 Quite Low
Neurotransmitter 30 40.56 Quite Low
Serotonin 21 38.72 Quite Low
sSRI 1 37.52 Quite Low
fibrosis 1 16.44 Low Low
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 684 100.00 Very High Very High Very High
Pressure And Volume Under Development 6 99.20 Very High Very High Very High
Adverse Drug Reaction 2 98.44 Very High Very High Very High
Obesity 3 98.00 Very High Very High Very High
Arrhythmia Under Development 4 94.76 High High
Myocardial Infarction 3 93.72 High High
Cardiovascular Disorder Under Development 4 91.56 High High
Suicidal Behaviour 3 89.68 High High
Convulsion 2 83.44 Quite High
Drug Dependence 19 75.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Guanfacine immediate release (GIR) is a nonstimulant adrenergic agonist commonly prescribed to control hypertension and has been also used for a number of years for the treatment of ADHD as an off-label alternative to stimulants, particularly in children and adolescent populations.80,81 The mechanism of action of guanfacine is largely attributed to its selective effects on ?
Regulation (years) of Localization (treatment) of ADHD associated with pressure and volume under development, agonist and attention deficit hyperactivity disorder
1) Confidence 0.38 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697545 Disease Relevance 0.86 Pain Relevance 0.14
Comings (2001) summarized the role of multiple genes in ADHD providing a polygenic model for the etiology of ADHD including the following salient points modified herein:


Regulation (polygenic) of Localization (etiology) of ADHD associated with attention deficit hyperactivity disorder
2) Confidence 0.18 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626918 Disease Relevance 0.97 Pain Relevance 0
Other exclusion criteria included adverse reactions or lack of response to previous amphetamine therapy, concomitant medications affecting the central nervous system or blood pressure (with the exception of ADHD medications that were washed out), pregnancy or lactation, a body mass index < 18.5 and ?
Regulation (affecting) of Neg (exception) Localization (exception) of ADHD in blood associated with adverse drug reaction, obesity, central nervous system and attention deficit hyperactivity disorder
3) Confidence 0.08 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2908054 Disease Relevance 1.44 Pain Relevance 0.09
Other exclusion criteria included adverse reactions or lack of response to previous amphetamine therapy, concomitant medications affecting the central nervous system or blood pressure (with the exception of ADHD medications that were washed out), pregnancy or lactation, a body mass index < 18.5 and ?
Regulation (affecting) of Localization (medications) of ADHD in blood associated with adverse drug reaction, obesity, central nervous system and attention deficit hyperactivity disorder
4) Confidence 0.08 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2908054 Disease Relevance 1.44 Pain Relevance 0.09

General Comments

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