INT258764

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.11
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Drd4) cytoplasm (Drd4) signal transducer activity (Drd4)
Drd4 (Rattus norvegicus)
ADHD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 194 100.00 Very High Very High Very High
gABA 18 94.16 High High
Catechol-O-methyltransferase 10 92.64 High High
Neurobehavioral 2 51.76 Quite High
Biofeedback 6 50.96 Quite High
depression 10 50.12 Quite High
Glutamate 2 45.28 Quite Low
Neurotransmitter 60 5.00 Very Low Very Low Very Low
Serotonin 42 5.00 Very Low Very Low Very Low
alcohol 28 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 608 100.00 Very High Very High Very High
Syndrome 58 79.60 Quite High
Affective Disorder 4 50.68 Quite High
Depression 12 50.12 Quite High
Conduct Disorder 46 49.48 Quite Low
Attention Deficit And Disruptive Behavior Disorders 26 49.32 Quite Low
Substance Abuse 36 5.00 Very Low Very Low Very Low
Tourette's Syndrome 34 5.00 Very Low Very Low Very Low
Tics 22 5.00 Very Low Very Low Very Low
Alcohol Addiction 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In terms of polygenic inheritance, Hawi et al (2005) observed that several genes are associated with ADHD, including DAT1, DBH, DRD4, DRD5 and 5HT1B.
DRD4 Binding (associated) of ADHD associated with attention deficit hyperactivity disorder
1) Confidence 0.08 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626918 Disease Relevance 0.47 Pain Relevance 0.23
A recent meta-analysis concluded that there is a significant association between ADHD and dopamine system genes, such as DAT1, but even more robust with regard to the DRD4 and DRD5 genes (Li et al 2006).
DRD4 Binding (association) of ADHD associated with dopamine and attention deficit hyperactivity disorder
2) Confidence 0.07 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626918 Disease Relevance 0.64 Pain Relevance 0.08

General Comments

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