INT258772

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.05
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DDC) small molecule metabolic process (DDC) lyase activity (DDC)
cellular nitrogen compound metabolic process (DDC) cellular amino acid metabolic process (DDC) cytoplasm (DDC)
DDC (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 37 97.56 Very High Very High Very High
GCH1 2 74.36 Quite High
gABA 2 45.92 Quite Low
Tetrahydrobiopterin 3 19.64 Low Low
Substantia nigra 2 5.00 Very Low Very Low Very Low
monoamine 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
GABAergic 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dyskinesias 15 54.40 Quite High
Disease 54 32.40 Quite Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low
Parkinson's Disease 4 5.00 Very Low Very Low Very Low
Toxicity 3 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Dementia 2 5.00 Very Low Very Low Very Low
Tremor 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Hypokinesia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, this apparently more simple approach could be more risky as there is no inherent feedback mechanism in the control of AADC activity and increased concentrations of AADC could lead to dopamine over production.
Regulation (control) of AADC associated with dopamine
1) Confidence 0.36 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626922 Disease Relevance 0.05 Pain Relevance 0.40

General Comments

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