INT258780

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Context Info
Confidence 0.13
First Reported 2008
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.77
Pain Relevance 1.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il23a) extracellular region (Il23a)
Anatomy Link Frequency
body 1
intestine 1
Il23a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 161 100.00 Very High Very High Very High
Cannabinoid 34 99.84 Very High Very High Very High
rheumatoid arthritis 90 99.06 Very High Very High Very High
psoriasis 136 98.52 Very High Very High Very High
Inflammation 89 94.28 High High
Multiple sclerosis 100 84.20 Quite High
chemokine 22 77.04 Quite High
Endocannabinoid 16 72.52 Quite High
Central nervous system 11 69.04 Quite High
Etanercept 18 68.40 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 91 99.06 Very High Very High Very High
Psoriasis 152 98.52 Very High Very High Very High
Disease 130 98.44 Very High Very High Very High
Nematode Infection 1 96.80 Very High Very High Very High
INFLAMMATION 95 94.28 High High
Targeted Disruption 18 93.08 High High
Sprains And Strains 87 90.24 High High
Infection 189 90.08 High High
Colitis 1 90.00 High High
Disease Progression 1 87.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
and Theiler’s virus were used to study the effects of cannabinoids on the regulation of IL-12 and IL-23 mRNA and protein IL-12 p40.
Regulation (regulation) of IL-23 mRNA associated with cannabinoid
1) Confidence 0.13 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626929 Disease Relevance 0.76 Pain Relevance 0.91
Furthermore, we show that in vivo modulation of the IL-23/IL-17A axis either by administration of exogenous cytokines (IL-17A or IL-23) or IL-17A depleting antibody, does not only result in immune modulation or altered bacterial clearance, but also directly affect resilience of animals to intranasal LVS infection, evident by clinical endpoints such as morbidity patterns (reflected by body weight) and cumulative survival.
Regulation (modulation) of IL-23 in body associated with body weight, sprains and strains, infection and cytokine
2) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.85 Pain Relevance 0.09
It is interesting that there was no significant change in the level of IL-23 in the jejunum of infected mice, which indicated that the function of IL-23 in nematode infection is not as important as it does in intestine inflammation induced by IL-10 knockout [10] or pathogenic CD4 T-cell transfer [30].
Neg (no) Regulation (change) of IL-23 in intestine associated with targeted disruption, inflammation and nematode infection
3) Confidence 0.11 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2786920 Disease Relevance 0.68 Pain Relevance 0.18
Ustekinumab, a monoclonal antibody targeting the p40 subunit of interleukin (IL)-12 and IL-23, is one such new agent.
Regulation (targeting) of IL-23
4) Confidence 0.11 Published 2010 Journal Biologics : Targets & Therapy Section Abstract Doc Link PMC2880344 Disease Relevance 0.92 Pain Relevance 0.33
In own experiments using oligonucleotide microarray technology to monitor disease course of rheumatoid arthritis patients by analysis of PBMC gene expression, values of IL-23, IL-17, and IL-22 were indeed generally below or only slightly above detection limits (unpublished observation).
Regulation (values) of IL-23 associated with rheumatoid arthritis and disease
5) Confidence 0.06 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.01 Pain Relevance 0.27
Particular focus is given to the role of the IL-12 cytokine family including IL-12, IL-23, IL-27, and IL-35, in host immunity to Candida.
Regulation (role) of IL-23 associated with cytokine
6) Confidence 0.04 Published 2011 Journal Clinical and Developmental Immunology Section Abstract Doc Link PMC2963117 Disease Relevance 0.55 Pain Relevance 0.18

General Comments

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