INT258791

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 5.73
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CDK1) mitochondrion (CDK1) protein complex assembly (CDK1)
cytoplasm (CDK1) cytosol (CDK1) mitosis (CDK1)
Anatomy Link Frequency
stem cell 1
T cells 1
CDK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 78 96.88 Very High Very High Very High
cytokine 24 85.96 High High
COX-2 inhibitor 52 84.80 Quite High
Osteoarthritis 33 82.88 Quite High
antagonist 7 77.96 Quite High
Bioavailability 19 66.56 Quite High
Kinase C 18 54.64 Quite High
Arthritis 2 50.00 Quite Low
cINOD 25 15.24 Low Low
Inflammation 75 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 81 99.40 Very High Very High Very High
Cancer 476 99.08 Very High Very High Very High
Frailty 34 98.20 Very High Very High Very High
Rheumatoid Arthritis 123 96.88 Very High Very High Very High
Hypoxia 42 94.52 High High
Neuroblastoma 4 93.48 High High
Obesity 7 89.28 High High
Papillomavirus Infection 123 88.72 High High
Reprotox - General 1 116 88.16 High High
Breast Cancer 50 87.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibition of mTOR circumvents the activation of the p34cdc2 kinase and thus the complexation with Cyclin E.
Positive_regulation (activation) of p34cdc2
1) Confidence 0.45 Published 2008 Journal International Journal of Nanomedicine Section Body Doc Link PMC2626933 Disease Relevance 0.16 Pain Relevance 0.11
Using a chemical inhibitor of CDK1, purvalanol A [19], we found that CDK1 activity is required for efficient infection by HPVs (Figure 6A).
Positive_regulation (required) of CDK1 associated with infection
2) Confidence 0.40 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2642596 Disease Relevance 0.42 Pain Relevance 0
If damage is detected, the G2/M checkpoint will inhibit the activation of the Cdc2/cyclin B1 complex, thereby preventing entry into mitosis until the damage has been repaired [23].
Positive_regulation (activation) of Cdc2
3) Confidence 0.36 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792351 Disease Relevance 0 Pain Relevance 0
The progression through G2 and M phases is orchestrated by the sequential activation and inactivation of the Cdc2/cyclin B1 complex.
Positive_regulation (activation) of Cdc2
4) Confidence 0.36 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792351 Disease Relevance 0 Pain Relevance 0
treatment of hFP-HEK cells leads to a delay in mitosis progression with elevated levels of cyclin B1 and increased Cdc2 kinase activity.
Positive_regulation (increased) of Cdc2
5) Confidence 0.36 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792351 Disease Relevance 0.17 Pain Relevance 0
The transition of cells from G2 to mitosis is dependent upon the completion of several events that culminate in the activation of the cyclin B/Cdc2 kinase complex [17].
Positive_regulation (activation) of Cdc2
6) Confidence 0.36 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792351 Disease Relevance 0.77 Pain Relevance 0.08
The Cdc25 proteins are phosphatases that activate Cdc2; therefore, their inactivation by genistein thereby inactivates Cdc2 and induces G2/M-phase arrest.
Positive_regulation (activate) of Cdc2
7) Confidence 0.36 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2933845 Disease Relevance 0.84 Pain Relevance 0
As shown in figure 3B, there was a corresponding increase in Cdc2 kinase activity following the treatment of hFP-HEK cells with PGF2?
Positive_regulation (increase) of Cdc2
8) Confidence 0.26 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792351 Disease Relevance 0 Pain Relevance 0
treatment of HEK cells stably expressing the human FP prostanoid receptor increases expression of cyclin B1 (A) and increases Cdc2-mediated phosphorylation of histone H1 (B).
Positive_regulation (increases) of Cdc2
9) Confidence 0.26 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792351 Disease Relevance 0 Pain Relevance 0
The Cdc25 proteins are phosphatases that activate Cdc2; therefore, their inactivation by genistein thereby inactivates Cdc2 and induces G2/M-phase arrest.
Positive_regulation (inactivates) of Cdc2
10) Confidence 0.26 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2933845 Disease Relevance 0.89 Pain Relevance 0
Thus, Cdks can be activated by phosphatases such as CDC25C (cell division cycle 25 homolog C) for CDK1 or kinase like CAK (Cdk activating kinase).
Positive_regulation (activated) of CDK1
11) Confidence 0.24 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.05 Pain Relevance 0.15
As a result, the fully differentiated cells exhibited de-differentiated stem cell behaviors, including active growth with CDK1, CDK2, RUNX3, and the upregulation of several stemness genes, Rex1 along with the definitive downregulation of mature differentiation markers (Figure 1G).
Positive_regulation (upregulation) of CDK1 in stem cell
12) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2817727 Disease Relevance 0.48 Pain Relevance 0
The formation of PIP3 leads to membrane localization and activation of phosphotidylinositol-dependent kinase-1 (PDK1) and AKT.17 The tumor suppressor phosphatase PTEN (phosphatase tensin homologue deleted on chromosome 10) dephosphorylates PIP3 reversing the action of PI3K.
Positive_regulation (activation) of phosphotidylinositol-dependent kinase-1 associated with cancer
13) Confidence 0.04 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004583 Disease Relevance 0.77 Pain Relevance 0
We identified elevated levels of phosphorylated (p)-AKT, p-p38, p-JNK, p-STAT1, p-STAT3, p-STAT5, p-ATF2, p-cdc2, p-p120, p-PKARIIb and p-src in joint infiltrating CD3+ T cells (Figure 1).
Positive_regulation (elevated) of p-cdc2 in T cells
14) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 1.19 Pain Relevance 0.40

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