INT258795

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.05
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cux1) Golgi apparatus (Cux1) nucleus (Cux1)
protein binding, bridging (Cux1) DNA binding (Cux1) cytoplasm (Cux1)
Anatomy Link Frequency
plasma 1
Cux1 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 62 99.68 Very High Very High Very High
antidepressant 1 97.76 Very High Very High Very High
Inflammation 42 93.08 High High
alcohol 2 89.00 High High
tolerance 4 81.80 Quite High
Hyperalgesia 1 73.12 Quite High
fibrosis 2 57.72 Quite High
rheumatoid arthritis 22 50.00 Quite Low
addiction 2 21.56 Low Low
withdrawal 2 20.88 Low Low
Disease Link Frequency Relevance Heat
Experimental Arthritis 6 99.68 Very High Very High Very High
Stress 10 93.60 High High
INFLAMMATION 42 93.08 High High
Arthritis 70 82.60 Quite High
Toxicity 2 76.56 Quite High
Osteolysis 2 73.84 Quite High
Hyperalgesia 1 73.12 Quite High
Fibrosis 2 57.72 Quite High
Rheumatoid Arthritis 22 50.00 Quite Low
Synovitis 24 44.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Only in one study, plasma concentrations of CDP and its metabolites were determined after 14 days (Cash et al. 1997).
CDP Binding (concentrations) of in plasma
1) Confidence 0.30 Published 2010 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2813522 Disease Relevance 0.22 Pain Relevance 0.16
CDP conjugation may be an attractive strategy for targeting MP and other immunosuppressive agents to their sites of action.



CDP Binding (conjugation) of
2) Confidence 0.16 Published 2008 Journal International Journal of Nanomedicine Section Body Doc Link PMC2626937 Disease Relevance 0.63 Pain Relevance 0.24
CDP conjugation of MP changed the water solubility of MP from insoluble (0.12 mg/mL) to highly soluble (>than 200 mg of CDP-MP/mL).
CDP Binding (conjugation) of
3) Confidence 0.14 Published 2008 Journal International Journal of Nanomedicine Section Body Doc Link PMC2626937 Disease Relevance 0.20 Pain Relevance 0.11

General Comments

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