INT258821

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Context Info
Confidence 0.57
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.32
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PLAT) protein modification process (PLAT) extracellular space (PLAT)
extracellular region (PLAT) cytoplasm (PLAT)
Anatomy Link Frequency
vascular endothelium 4
platelet 2
PLAT (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 21 99.04 Very High Very High Very High
cva 57 94.36 High High
cytokine 3 83.28 Quite High
corticosteroid 2 79.52 Quite High
fibrosis 1 67.76 Quite High
Angina 3 36.60 Quite Low
beta blocker 1 8.56 Low Low
bradykinin 8 5.00 Very Low Very Low Very Low
aspirin 7 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 24 99.62 Very High Very High Very High
INFLAMMATION 23 99.04 Very High Very High Very High
Thrombosis 18 98.80 Very High Very High Very High
Hemorrhage 28 94.36 High High
Pathologic Constriction 9 93.68 High High
False Aneurysm 2 92.76 High High
Coronary Aneurysm 3 91.20 High High
Myocardial Infarction 13 90.48 High High
Diabetes Mellitus 8 89.36 High High
Endarteritis 1 88.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
by stimulating the release of plasminogen activator inhibitor type 1 and by reducing the release of t-PA through the extrinsic route [30], the release of TNF-?
Negative_regulation (reducing) of Localization (release) of t-PA
1) Confidence 0.57 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2891694 Disease Relevance 0.39 Pain Relevance 0.19
The primary reason for clots seems to reside in the inflammatory process that leads to platelet aggregation and decrease in release of tissue plasminogen activator.
Negative_regulation (decrease) of Localization (release) of tissue plasminogen activator in platelet associated with inflammation
2) Confidence 0.25 Published 2008 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2627529 Disease Relevance 1.94 Pain Relevance 0.19
The present study demonstrates that inhalation of diesel exhaust generated under urban ETC running conditions, causes a reduction in endothelium-dependent and endothelium-independent vasodilatation, together with an impairment of t-PA release from the vascular endothelium.
Negative_regulation (impairment) of Localization (release) of t-PA in vascular endothelium associated with increased venous pressure under development
3) Confidence 0.09 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2918524 Disease Relevance 0.28 Pain Relevance 0
Mesoglycan seems effective in restoring defective fibrinolysis in patients affected by cutaneous necrotizing venulitis [10], suggesting that in inflammatory vasculitis, characterized by a reduced cutaneous fibrinolysis (reduced release of tPA from the vascular endothelium), the use of a fibrinolytic agent should be considered.

2.

Negative_regulation (reduced) of Localization (release) of tPA in vascular endothelium associated with inflammation and increased venous pressure under development
4) Confidence 0.07 Published 2010 Journal International Journal of Vascular Medicine Section Body Doc Link PMC2989756 Disease Relevance 0.71 Pain Relevance 0.05

General Comments

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