INT258861

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Context Info
Confidence 0.14
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.88
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DOA, HLA-DRB1) plasma membrane (HLA-DOA, HLA-DRB1) Golgi apparatus (HLA-DRB1)
endoplasmic reticulum (HLA-DRB1)
HLA-DOA (Homo sapiens)
HLA-DRB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 49 98.56 Very High Very High Very High
spinal inflammation 1 97.76 Very High Very High Very High
rheumatoid arthritis 1 97.76 Very High Very High Very High
Central nervous system 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 2 99.76 Very High Very High Very High
Celiac Disease 1 99.08 Very High Very High Very High
Demyelinating Disease 51 98.56 Very High Very High Very High
Low Back Pain 1 97.76 Very High Very High Very High
Rheumatoid Arthritis 1 97.76 Very High Very High Very High
Sleep Disorders 1 95.48 Very High Very High Very High
Disease 28 89.16 High High
Diabetes Mellitus 1 83.28 Quite High
Neonatal Alloimmune Thrombocytopenia 4 72.56 Quite High
Iron Overload 6 67.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The HLA-A1, B8, DR17 haplotype is frequently associated with autoimmune disorders.
HLA Binding (associated) of DR1 associated with autoimmune disease
1) Confidence 0.14 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 1.44 Pain Relevance 0.15
These studies imply direct interactions between HLA-DRB1, the main susceptibility locus for MS, and vitamin D, a strong candidate for mediating the environmental effect.
HLA Binding (interactions) of DRB1 associated with multiple sclerosis
2) Confidence 0.02 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2627899 Disease Relevance 0.44 Pain Relevance 0.13

General Comments

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