INT258920

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Context Info
Confidence 0.22
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.02
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CASR) signal transducer activity (CASR)
Anatomy Link Frequency
parathyroid gland 1
parathyroid 1
CASR (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 2 85.28 High High
Pain 20 75.24 Quite High
rheumatoid arthritis 2 49.48 Quite Low
spinal inflammation 1 43.28 Quite Low
fibrosis 110 26.24 Quite Low
Inflammation 5 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Iron Overload 6 100.00 Very High Very High Very High
Hypercalcemia 17 96.32 Very High Very High Very High
Bone Cancer 27 95.20 Very High Very High Very High
Congenital Anomalies 4 94.00 High High
Renal Disease 3 90.40 High High
Osteoporosis 17 85.76 High High
Chronic Renal Failure 3 82.88 Quite High
Disease 19 79.88 Quite High
Hypocalcemia 2 78.64 Quite High
Pain 21 75.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cinacalcet (Sensipar®, Amgen, USA), a type II calcimimetic, allosterically increases the sensitivity of the calcium-sensing receptor, lowering the threshold for activation, and thereby decreasing secretion of parathyroid hormone (PTH) [1].
Regulation (sensitivity) of calcium-sensing receptor in parathyroid
1) Confidence 0.22 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2907400 Disease Relevance 0.95 Pain Relevance 0.14
The most common mutation responsible for HHC is a single amino acid substitution in the ?
Regulation (responsible) of HHC associated with iron overload
2) Confidence 0.11 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 0.80 Pain Relevance 0
Allosteric modulations of the G-protein coupled calcium-sensing receptor in the parathyroid gland can affect PTH release.
Regulation (modulations) of G-protein coupled calcium-sensing receptor in parathyroid gland
3) Confidence 0.04 Published 2011 Journal Journal of Osteoporosis Section Body Doc Link PMC3010683 Disease Relevance 0.27 Pain Relevance 0.04

General Comments

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