INT258945

Context Info Confidence 0.21 First Reported 2007 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 4.52 Pain Relevance 0

structural molecule activity (KRT18) cell cycle (KRT18) microtubule organizing center (KRT18) cytoplasm (KRT18)

KRT18 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 1 49.52 metalloproteinase 3 5.00 Chronic pancreatitis 1 5.00 tolerance 1 5.00 wide dynamic range 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Necrosis 1 99.36 Cleidocranial Dysplasia 98 99.28 Adamantinoma 80 98.96 Breast Cancer 2 98.56 Apoptosis 6 98.40 Sarcoma 1 97.66 Chordoma 1 97.20 Synovial Sarcoma 1 97.00 Generaliased Trisomy 1 96.68 Metastasis 7 88.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

According to a study on the antibodies against a subtype of cytokeratin by Hazelbag et al, cytokeratin (CK) in AD is different from synovial sarcoma, chordoma, or epithelial sarcoma.13 Benassi et al. insisted on a correlation between OFD and AD based on their results that showed positive CK19 and negative CK8 and CK18 staining in both OFD and AD cases.12 In a cytogenetic study, both OFD and AD have trisomies on chromosomes 7, 8, and 12.4,16

Positive_regulation (negative) of CK18 associated with sarcoma, adamantinoma, cleidocranial dysplasia, synovial sarcoma, generaliased trisomy and chordoma

1) Confidence 0.21 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628088 Disease Relevance 3.07 Pain Relevance 0

Presence of caspase cleaved CK18 has been shown to be a reliable marker of apoptosis, while release of intact CK18 reflects necrosis.39 Increased levels of caspase-cleaved CK18 have been measured in the serum of breast cancer patients when compared with controls.40

Positive_regulation (cleaved) of CK18 associated with necrosis, breast cancer and apoptosis

2) Confidence 0.14 Published 2009 Journal Journal of Proteome Research Section Body Doc Link PMC2652408 Disease Relevance 1.45 Pain Relevance 0

General Comments

This test has worked.