INT258945

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Context Info
Confidence 0.21
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 4.52
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (KRT18) cell cycle (KRT18) microtubule organizing center (KRT18)
cytoplasm (KRT18)
KRT18 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1 49.52 Quite Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
Chronic pancreatitis 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
wide dynamic range 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 1 99.36 Very High Very High Very High
Cleidocranial Dysplasia 98 99.28 Very High Very High Very High
Adamantinoma 80 98.96 Very High Very High Very High
Breast Cancer 2 98.56 Very High Very High Very High
Apoptosis 6 98.40 Very High Very High Very High
Sarcoma 1 97.66 Very High Very High Very High
Chordoma 1 97.20 Very High Very High Very High
Synovial Sarcoma 1 97.00 Very High Very High Very High
Generaliased Trisomy 1 96.68 Very High Very High Very High
Metastasis 7 88.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
According to a study on the antibodies against a subtype of cytokeratin by Hazelbag et al, cytokeratin (CK) in AD is different from synovial sarcoma, chordoma, or epithelial sarcoma.13 Benassi et al. insisted on a correlation between OFD and AD based on their results that showed positive CK19 and negative CK8 and CK18 staining in both OFD and AD cases.12 In a cytogenetic study, both OFD and AD have trisomies on chromosomes 7, 8, and 12.4,16
Positive_regulation (negative) of CK18 associated with sarcoma, adamantinoma, cleidocranial dysplasia, synovial sarcoma, generaliased trisomy and chordoma
1) Confidence 0.21 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628088 Disease Relevance 3.07 Pain Relevance 0
Presence of caspase cleaved CK18 has been shown to be a reliable marker of apoptosis, while release of intact CK18 reflects necrosis.39 Increased levels of caspase-cleaved CK18 have been measured in the serum of breast cancer patients when compared with controls.40
Positive_regulation (cleaved) of CK18 associated with necrosis, breast cancer and apoptosis
2) Confidence 0.14 Published 2009 Journal Journal of Proteome Research Section Body Doc Link PMC2652408 Disease Relevance 1.45 Pain Relevance 0

General Comments

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