INT258953

Context Info Confidence 0.19 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.53 Pain Relevance 0.14

cell morphogenesis (Bcl6) nucleus (Bcl6) intracellular (Bcl6) DNA binding (Bcl6)

Anatomy Link Frequency epithelium 2 Bcl6 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 18 92.64 fibrosis 2 5.00 Pain 2 5.00 Inflammatory response 2 5.00 alcohol 2 5.00

Disease Link Frequency Relevance Heat Otitis Media With Effusion 82 99.84 Metaplasia 26 99.64 INFLAMMATION 20 92.64 Infection 18 89.44 Lymphatic System Cancer 4 74.72 Otitis Media 12 50.00 Hyperplasia 4 5.00 Mouth Breathing 4 5.00 Bacterial Infection 4 5.00 Snoring 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In conclusion, we observed significant decreases in the respiratory epithelium of adenoid mucosa, significant increases of squamous epithelial metaplasia, and significant reductions of BCL-6 expression in OME patients.

Negative_regulation (reductions) of Gene_expression (expression) of BCL-6 in epithelium associated with metaplasia and otitis media with effusion

1) Confidence 0.19 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628093 Disease Relevance 0.80 Pain Relevance 0.07

Since we measured BCL-6 expression only after antigen stimulation, and since BCL-6 staining occurred primarily in the germinal centers, it may be that this transcription factor directly controls IgA production in the germinal centers.

Negative_regulation (measured) of Gene_expression (expression) of BCL-6

2) Confidence 0.14 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628093 Disease Relevance 0.73 Pain Relevance 0.07

General Comments

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