INT258962

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.47
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
macrophage 1
Saa (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 13 93.36 High High
Arthritis 3 91.68 High High
spinal inflammation 41 87.08 High High
cytokine 6 77.40 Quite High
Inflammatory response 1 46.80 Quite Low
rheumatoid arthritis 4 38.88 Quite Low
cINOD 4 5.00 Very Low Very Low Very Low
spondylitis 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Tendonitis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 6 98.64 Very High Very High Very High
Amyloidosis 6 95.80 Very High Very High Very High
INFLAMMATION 13 93.36 High High
Increased Venous Pressure Under Development 1 92.46 High High
Cancer 4 92.12 High High
Infection 3 91.90 High High
Arthritis 3 91.68 High High
Disease 33 91.06 High High
Low Back Pain 44 87.08 High High
Polymyalgia Rheumatica 4 39.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been reported that SAA has an influence on the pathogenesis of several diseases such as inflammatory arthritis, infection, neoplasia, atherosclerosis (by means of both pro- and anti-inflammatory activities, and by changing the cholesterol metabolism and transport).31-33 Moreover, SAA can cause secondary amyloidosis, derived from deposits of amyloid fibrils and plaques in specific organs.33 The precise mechanisms involved in amyloid formation and deposition are poorly understood, but amyloidogenic factors like incomplete proteolysis of SAA or both initiation and growth of amyloid fibrils by macrophage have been proposed.33,34 Even though the role of SAA in amyloidogenesis still remains unclear, it is certain that high concentrations and long exposure of SAA in serum are the most important pathogenic factors.21,33 In the present study, one of patients with AS had renal amyloidosis confirmed by renal biopsy.
Protein_catabolism (proteolysis) of SAA in macrophage associated with spinal inflammation, alzheimer's dementia, increased venous pressure under development, disease, infection, inflammation, amyloidosis, cancer and arthritis
1) Confidence 0.43 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628111 Disease Relevance 1.47 Pain Relevance 0.44

General Comments

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