INT258999

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Context Info
Confidence 0.16
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.94
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Relt) molecular_function (Relt) cellular_component (Relt)
cytoplasm (Relt)
Anatomy Link Frequency
T cells 1
Relt (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 1 80.64 Quite High
Sciatica 3 78.64 Quite High
backache 1 78.00 Quite High
cytokine 4 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Cauda equina syndrome 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 5 100.00 Very High Very High Very High
Cancer 5 100.00 Very High Very High Very High
Autoimmune Disease 10 98.72 Very High Very High Very High
Injury 1 81.32 Quite High
INFLAMMATION 4 80.28 Quite High
Nerve Root Compression 3 78.64 Quite High
Low Back Pain 1 78.00 Quite High
Intervertebral Disk Displacement 9 70.60 Quite High
Disease Progression 1 50.80 Quite High
Spinal Fractures 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AITR (Activation-Inducible Tumor necrosis factor Receptor) and AITRL (AITR Ligand) are both costimulatory molecules, which are pairs of molecules that interact with each other and are expressed at high levels on the surface of CD4+CD25+ T cells.9 When these costimulatory molecules are activated, they inhibit the ability of the CD4+CD25+ T cells to suppress the autoreactive T-cells.10 This results in an increased autoimmune response.
Gene_expression (expressed) of Tumor necrosis factor Receptor in T cells associated with necrosis and cancer
1) Confidence 0.16 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628152 Disease Relevance 0.94 Pain Relevance 0.20

General Comments

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