INT259006

Context Info Confidence 0.13 First Reported 2007 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.39 Pain Relevance 0

Cd19 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 4 19.12 Inflammation 3 5.32 methotrexate 3 5.00 dexamethasone 3 5.00 Sciatica 3 5.00 vincristine 3 5.00 palliative 1 5.00 Central nervous system 1 5.00 Inflammatory response 1 5.00 intrathecal 1 5.00

Disease Link Frequency Relevance Heat Lymphatic System Cancer 82 94.72 Chronic Lymphoid Leukemia 14 89.32 Intervertebral Disk Displacement 9 89.28 Multiple Myeloma 8 72.80 Acquired Immune Deficiency Syndrome Or Hiv Infection 4 68.40 Htlv Types I And Ii 5 68.20 Disease 39 68.00 Mantle-cell Lymphoma 13 58.44 Follicular Lymphoma 13 57.40 Cancer 18 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Antibodies targeting CD19, CD20, CD22, in combination with a toxin, CD23, CD40, CD80, and HLA-DR are being evaluated in clinical trials, and their additional benefit will be evaluated in coming years (DiJoseph et al 2004, 2006; Byrd et al 2005; Czuczman et al 2005; Foreno-Torres et al 2006).

Regulation (targeting) of CD19

1) Confidence 0.13 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727901 Disease Relevance 1.22 Pain Relevance 0

No significant differences could be found between the patients and the controls for the other cell markers, such as CD4, CD8, CD19, and CD55, from the disc tissue cells or the PBMC.

Regulation (controls) of CD19

2) Confidence 0.04 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628152 Disease Relevance 0.16 Pain Relevance 0

General Comments

This test has worked.