INT259007

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Context Info
Confidence 0.34
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 4.94
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Tnfrsf18) plasma membrane (Tnfrsf18)
Anatomy Link Frequency
blood 2
nerve 1
T-cell 1
Tnfrsf18 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 26 99.56 Very High Very High Very High
Nerve growth factor 2 97.40 Very High Very High Very High
cytokine 108 78.72 Quite High
Inflammation 91 64.92 Quite High
metalloproteinase 9 47.72 Quite Low
Pain 2 41.52 Quite Low
chemokine 6 34.08 Quite Low
adenocard 6 31.44 Quite Low
Sciatica 27 5.00 Very Low Very Low Very Low
Inflammatory response 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 111 100.00 Very High Very High Very High
Necrosis 49 100.00 Very High Very High Very High
Intervertebral Disk Displacement 81 99.48 Very High Very High Very High
Autoimmune Disease 114 96.56 Very High Very High Very High
Spinal Fractures 36 84.28 Quite High
INFLAMMATION 96 64.92 Quite High
Pain 2 41.52 Quite Low
Repression 4 13.68 Low Low
Disease 44 10.72 Low Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 10.40 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Human activation-inducible tumor necrosis factor receptor (AITR) and its ligand, AITRL, are important costimulatory molecules in the pathogenesis of autoimmune diseases.
Positive_regulation (activation) of AITR associated with necrosis, autoimmune disease and cancer
1) Confidence 0.34 Published 2007 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2628152 Disease Relevance 0.67 Pain Relevance 0
In a similar fashion, AITR and AITRL might be increased in both the disc tissue and PBMC in patients with a lumbar disc herniation.
Positive_regulation (increased) of AITR
2) Confidence 0.30 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628152 Disease Relevance 0.44 Pain Relevance 0.03
This may be the first study to demonstrate that patients with lumbar disc herniation have a significantly increased AITR and AITRL expression in herniated disc tissue and in peripheral blood.
Positive_regulation (increased) of AITR in blood associated with intervertebral disk displacement
3) Confidence 0.24 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628152 Disease Relevance 0.42 Pain Relevance 0
Human activation-inducible tumor necrosis factor receptor (AITR) and its ligand, AITRL, are important costimulatory molecules in the pathogenesis of autoimmune diseases.
Positive_regulation (inducible) of AITR associated with necrosis, autoimmune disease and cancer
4) Confidence 0.23 Published 2007 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2628152 Disease Relevance 0.67 Pain Relevance 0
Flow cytometric analysis revealed significantly higher levels of both AITR and AITRL in the lumbar disc herniation patients than in the controls.
Positive_regulation (levels) of AITR
5) Confidence 0.20 Published 2007 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2628152 Disease Relevance 0.52 Pain Relevance 0
The herniation patients had significantly higher levels of AITR and AITRL than did the controls; these levels are expressed as the percentages of cells from the disc tissue (mean ± SD), AITR: 12.15 ± 5.16% versus 6.84 ± 1.76%, p < 0.05, AITRL: 39.43 ± 8.57 versus 18.71 ± 5.56%, p < 0.05) (Fig. 1).
Positive_regulation (levels) of AITR
6) Confidence 0.20 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628152 Disease Relevance 0.20 Pain Relevance 0.14
The AITR and AITRL are increased in both the herniated disc tissue and the peripheral blood of patients with lumbar disc herniation.



Positive_regulation (increased) of AITR in blood associated with intervertebral disk displacement
7) Confidence 0.20 Published 2007 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2628152 Disease Relevance 0.31 Pain Relevance 0
Finally, soluble AITR and AITRL were elevated in the patients with lumbar disc herniations.


Positive_regulation (elevated) of AITR
8) Confidence 0.20 Published 2007 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2628152 Disease Relevance 0.32 Pain Relevance 0
The discs and PBMC from patients with symptomatic herniations were found to have significantly higher levels of AITR and/or AITRL than matched controls.
Positive_regulation (levels) of AITR
9) Confidence 0.20 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628152 Disease Relevance 0.29 Pain Relevance 0
Stimulation of GITR abrogate CD4+CD25+ T-cell-mediated suppression and administration of a monoclonal antibody to GITR produce organ-specific autoimmune disease in otherwise normal mice [46].
Positive_regulation (Stimulation) of GITR in T-cell associated with autoimmune disease
10) Confidence 0.19 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821644 Disease Relevance 0.54 Pain Relevance 0.10
Tregs also express the glucocorticoid-induced tumor necrosis factor receptor family-related gene (GITR, also known as TNFRSF18), a member of the tumor necrosis factor-nerve growth factor (TNF-NGF) receptor gene superfamily, which plays a key role in dominant immunological self-tolerance [45].
Positive_regulation (induced) of GITR in nerve associated with necrosis, nerve growth factor, cancer and tolerance
11) Confidence 0.19 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821644 Disease Relevance 0.55 Pain Relevance 0.10

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