INT259012

Context Info Confidence 0.27 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 6 Disease Relevance 2.82 Pain Relevance 0.06

signal transduction (TNFSF18) extracellular space (TNFSF18) plasma membrane (TNFSF18) cell-cell signaling (TNFSF18)

Anatomy Link Frequency blood 2 TNFSF18 (Homo sapiens)

Pain Link Frequency Relevance Heat Sciatica 18 64.96 imagery 6 48.24 Inflammatory response 6 38.48 backache 6 35.84 Cauda equina syndrome 6 31.20 Inflammation 18 13.52 cytokine 24 7.68 metalloproteinase 6 7.16

Disease Link Frequency Relevance Heat Intervertebral Disk Displacement 54 99.84 Autoimmune Disease 60 95.04 Disease Progression 6 89.84 Necrosis 30 85.56 Cancer 30 85.20 Spinal Fractures 24 84.28 Nerve Root Compression 18 64.96 Injury 6 39.16 INFLAMMATION 24 38.12 Low Back Pain 6 35.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The purpose of the present study is to investigate whether the overexpression of AITR and AITRL might be associated with lumbar disc herniation.

Positive_regulation (overexpression) of Gene_expression (overexpression) of AITRL

1) Confidence 0.27 Published 2007 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2628152 Disease Relevance 0.68 Pain Relevance 0

This phenomenon was not observed in healthy control groups, suggesting that the increased expression of AITR and AITRL might play a specific pathogenic role in lumbar disc herniation.

Positive_regulation (increased) of Gene_expression (expression) of AITRL

2) Confidence 0.24 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628152 Disease Relevance 0.41 Pain Relevance 0

This may be the first study to demonstrate that patients with lumbar disc herniation have a significantly increased AITR and AITRL expression in herniated disc tissue and in peripheral blood.

Positive_regulation (increased) of Gene_expression (expression) of AITRL in blood associated with intervertebral disk displacement

3) Confidence 0.20 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628152 Disease Relevance 0.42 Pain Relevance 0

The AITRL expression levels were also increased in patients with lumbar disc herniation, shown by using confocal laser scanning microscopy, immunohistochemistry and RT-PCR.

Positive_regulation (increased) of Gene_expression (expression) of AITRL

4) Confidence 0.18 Published 2007 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2628152 Disease Relevance 0.45 Pain Relevance 0

The purpose of the present study is to determine if AITR and AITRL are overexpressed in symptomatic lumbar disc herniation patients.

Positive_regulation (overexpressed) of Gene_expression (overexpressed) of AITRL

5) Confidence 0.17 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628152 Disease Relevance 0.66 Pain Relevance 0.06

There was increased expression of AITRL and slightly increased expression of AITR on the herniated disc cells, but not in the controls (Fig. 6).

Positive_regulation (increased) of Gene_expression (expression) of AITRL associated with intervertebral disk displacement

6) Confidence 0.16 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628152 Disease Relevance 0.19 Pain Relevance 0

General Comments

This test has worked.