INT259017

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Context Info
Confidence 0.08
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.27
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TNFSF18, Tnfrsf18) signal transduction (TNFSF18) extracellular space (TNFSF18)
extracellular region (Tnfrsf18) cell-cell signaling (TNFSF18)
Anatomy Link Frequency
regulatory T cells 1
TNFSF18 (Homo sapiens)
Tnfrsf18 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 6 87.84 High High
metalloproteinase 2 81.48 Quite High
cytokine 8 74.08 Quite High
Sciatica 6 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
backache 2 5.00 Very Low Very Low Very Low
Cauda equina syndrome 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 10 99.64 Very High Very High Very High
Cancer 10 99.46 Very High Very High Very High
Autoimmune Disease 20 98.24 Very High Very High Very High
Intervertebral Disk Displacement 18 90.28 High High
INFLAMMATION 8 87.84 High High
Spinal Fractures 8 53.84 Quite High
Nerve Root Compression 6 5.00 Very Low Very Low Very Low
Polyradiculopathy 2 5.00 Very Low Very Low Very Low
Low Back Pain 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Human activation-inducible tumor necrosis factor receptor (AITR) and its ligand, AITRL, are important costimulatory molecules in the pathogenesis of autoimmune diseases.
AITRL Binding (ligand) of AITR associated with necrosis, autoimmune disease and cancer
1) Confidence 0.08 Published 2007 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2628152 Disease Relevance 0.67 Pain Relevance 0
Autoimmunity is normally prevented by another type of T cells, which are a lineage of the CD4+CD25+ regulatory T-cells, that suppress pathologic T cells.7,8 Both the AITR and AITRL have been shown to interact with one another in order to inhibit these autoimmunity-suppressing CD4+CD25+ regulatory T cells.10,17 Furthermore, blocking these costimulatory molecules restores the capacity of the CD4+CD25+ regulatory T cells to suppress the pathogenic, autoreactive T cells, thereby preventing autoimmunity.17-20
AITRL Binding (interact) of AITR in regulatory T cells associated with autoimmune disease
2) Confidence 0.08 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628152 Disease Relevance 0.59 Pain Relevance 0.16

General Comments

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