INT259051

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.48
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (TP53, UBE3A) cytosol (TP53, UBE3A) cell differentiation (TP53)
nucleoplasm (TP53) mitochondrion (TP53) DNA binding (TP53)
TP53 (Homo sapiens)
UBE3A (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 3 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Papillomavirus Infection 1686 95.72 Very High Very High Very High
Death 3 88.08 High High
Chromosome Aberrations 3 86.32 High High
Genomic Instability 3 84.84 Quite High
Apoptosis 3 68.24 Quite High
Cervical Cancer 315 64.96 Quite High
Cancer 93 61.72 Quite High
Retinoblastoma 3 61.28 Quite High
Infection 195 59.20 Quite High
Malignant Neoplastic Disease 12 37.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
E6 first associates with the cellular ubiquitin ligase protein termed E6-associated protein (E6AP), then the E6-E6AP complex binds to p53, stimulating its ubiquitination and degradation [49].
p53 Binding (complex) of E6AP
1) Confidence 0.01 Published 2008 Journal Infect Agent Cancer Section Body Doc Link PMC2628336 Disease Relevance 1.16 Pain Relevance 0
E6 first associates with the cellular ubiquitin ligase protein termed E6-associated protein (E6AP), then the E6-E6AP complex binds to p53, stimulating its ubiquitination and degradation [49].
p53 Binding (binds) of E6AP
2) Confidence 0.01 Published 2008 Journal Infect Agent Cancer Section Body Doc Link PMC2628336 Disease Relevance 1.16 Pain Relevance 0
E6 first associates with the cellular ubiquitin ligase protein termed E6-associated protein (E6AP), then the E6-E6AP complex binds to p53, stimulating its ubiquitination and degradation [49].
p53 Binding (binds) of E6AP
3) Confidence 0.01 Published 2008 Journal Infect Agent Cancer Section Body Doc Link PMC2628336 Disease Relevance 1.16 Pain Relevance 0

General Comments

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