INT25906

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Context Info
Confidence 0.29
First Reported 1989
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 5.41
Pain Relevance 3.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cish)
Anatomy Link Frequency
spinal cord 1
photoreceptor cells 1
brain 1
Cish (Rattus norvegicus)
Pain Link Frequency Relevance Heat
abatacept 95 100.00 Very High Very High Very High
Infliximab 93 100.00 Very High Very High Very High
medulla 9 98.84 Very High Very High Very High
Inflammation 19 98.68 Very High Very High Very High
Spinal cord 19 97.28 Very High Very High Very High
Multiple sclerosis 306 94.44 High High
cytokine 52 94.32 High High
opioid receptor 1 92.40 High High
methotrexate 20 90.20 High High
Antinociceptive 1 88.40 High High
Disease Link Frequency Relevance Heat
Syndrome 132 100.00 Very High Very High Very High
INFLAMMATION 20 98.68 Very High Very High Very High
Retinal Degeneration 29 95.84 Very High Very High Very High
Glioma 3 94.88 High High
Neuroblastoma 1 94.52 High High
Demyelinating Disease 355 94.44 High High
Autoimmune Disease 6 89.12 High High
Optic Disorders 3 88.00 High High
Disease 102 87.12 High High
Systemic Lupus Erythematosus 13 86.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, (+)-cis-4 is the most effective inhibitor of adenylate cyclase in these membranes, (+)-trans-4 has weak activity, and the levo enantiomers are inactive.
Negative_regulation (inhibitor) of cis-4
1) Confidence 0.29 Published 1989 Journal J. Med. Chem. Section Abstract Doc Link 2542560 Disease Relevance 0.19 Pain Relevance 0.24
SOCS-2 mRNA was decreased in CLP-PN rats compared with Sham-PN rats (P = 0.07).
Negative_regulation (decreased) of SOCS
2) Confidence 0.19 Published 2007 Journal Crit Care Section Abstract Doc Link PMC2206515 Disease Relevance 0.14 Pain Relevance 0.26
It has been suggested that monthly triple-dose Gd-enhanced MRIs accurately detected inflammation which is an important factor in the pathogenesis of brain tissue loss in CIS patients (Paolillo et al 2004).
Negative_regulation (loss) of CIS in brain associated with inflammation and syndrome
3) Confidence 0.17 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2500255 Disease Relevance 1.85 Pain Relevance 0.52
Differential diagnosis of CIS affecting the optic nerves, brainstem, and
                       spinal cord
Negative_regulation (diagnosis) of CIS in spinal cord associated with medulla, syndrome and spinal cord
4) Confidence 0.07 Published 2008 Journal Multiple Sclerosis (Houndmills, Basingstoke, England) Section Body Doc Link PMC2850590 Disease Relevance 1.33 Pain Relevance 0.63
A more clear definition of CIS was
                   developed. 
Negative_regulation (definition) of CIS associated with syndrome
5) Confidence 0.07 Published 2008 Journal Multiple Sclerosis (Houndmills, Basingstoke, England) Section Body Doc Link PMC2850590 Disease Relevance 1.25 Pain Relevance 0.31
Frasson and colleagues (1999) first described the rescue of rod photoreceptor cells by a Ca2+ channel blocker, D-cis-diltiazem, in rd mouse, in which the gene encoding cGMP phosphodiesterase is affected.
Negative_regulation (blocker) of D-cis-diltiazem in photoreceptor cells
6) Confidence 0.05 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699806 Disease Relevance 0.36 Pain Relevance 0
However, by day 365, the 95% CIs for the treatment difference between abatacept and infliximab for the reduction in DAS28 (ESR), good EULAR responses, LDAS, the ACR 20 response rate and the HRQoL physical summary measure did not include zero, suggesting a difference favouring abatacept for these specific endpoints.
Negative_regulation (reduction) of CIs associated with infliximab and abatacept
7) Confidence 0.01 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564802 Disease Relevance 0.28 Pain Relevance 1.22

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