INT259063

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.15
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (UBE3A) protein modification process (UBE3A) nucleus (UBE3A)
intracellular (UBE3A) ligase activity (UBE3A)
UBE3A (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 1 90.84 High High
Glutamate receptor 8 90.52 High High
tetrodotoxin 5 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
nMDA receptor 2 5.00 Very Low Very Low Very Low
Action potential 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
potassium channel 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Papillomavirus Infection 562 94.96 High High
Death 1 87.52 High High
Chromosome Aberrations 1 85.56 High High
Genomic Instability 1 84.08 Quite High
Apoptosis 1 67.68 Quite High
Cervical Cancer 105 64.40 Quite High
Cancer 31 60.96 Quite High
Retinoblastoma 1 60.52 Quite High
Infection 65 58.64 Quite High
Malignant Neoplastic Disease 4 36.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
h, this agent caused a prolonged decrease in the activity of the ubiquitin-proteasome system as shown by disassembly of 26S proteasomes, decrease in ubiquitin-protein conjugates, and dissociation of the ubiquitin ligases UBE3A (E6-AP) and HUWE1 from the proteasome.
E6-AP Binding (ligases) of
1) Confidence 0.36 Published 2010 Journal Frontiers in Molecular Neuroscience Section Abstract Doc Link PMC2901091 Disease Relevance 0 Pain Relevance 0.09
E6 first associates with the cellular ubiquitin ligase protein termed E6-associated protein (E6AP), then the E6-E6AP complex binds to p53, stimulating its ubiquitination and degradation [49].
E6AP Binding (binds) of
2) Confidence 0.06 Published 2008 Journal Infect Agent Cancer Section Body Doc Link PMC2628336 Disease Relevance 1.15 Pain Relevance 0

General Comments

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