INT259086

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Context Info
Confidence 0.22
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.27
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpc1) protein complex (Trpc1) transmembrane transport (Trpc1)
cytoplasm (Trpc1)
Anatomy Link Frequency
adult brain 1
dorsal root ganglion 1
Trpc1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 38 100.00 Very High Very High Very High
withdrawal 2 100.00 Very High Very High Very High
Calcitonin gene-related peptide 15 99.62 Very High Very High Very High
TRP channel 42 94.56 High High
IPN 20 93.20 High High
allodynia 35 91.76 High High
GABAergic 4 87.64 High High
Thermal hyperalgesia 36 85.04 High High
Inflammation 13 50.00 Quite Low
Root ganglion neuron 1 50.00 Quite Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 39 100.00 Very High Very High Very High
Inflammatory Pain 20 93.20 High High
Neuropathic Pain 35 91.76 High High
Hyperalgesia 40 85.04 High High
Targeted Disruption 7 80.72 Quite High
INFLAMMATION 13 50.00 Quite Low
Nociception 5 50.00 Quite Low
Cancer Pain 1 47.00 Quite Low
Bone Cancer 1 46.80 Quite Low
Diabetic Neuropathy 1 45.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
50 mV (TRPC1, Fig. 3A, mean ?
TRPC1 Binding (mean) of
1) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3002943 Disease Relevance 0 Pain Relevance 0.04
TRPC3 and TRPC6 can form a heteromeric channel complex with TRPC1, TRPC4 and TRPC5 in rat embryonic brain, but not in adult brain [10].
TRPC1 Neg (not) Binding (complex) of in adult brain
2) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866321 Disease Relevance 0.22 Pain Relevance 0.28
AUC: area under the curve; CFA: complete Freund's adjuvant; CGRP: calcitonin gene-related peptide; DRG: dorsal root ganglion; HPL: hot plate latency; IB4: isolectin B4; NF200: neurofilament 200; PWT: paw withdrawal threshold; TRPV1: transient receptor potential vanilloid 1.


transient receptor potential vanilloid 1 Binding (ganglion) of in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, withdrawal and calcitonin gene-related peptide
3) Confidence 0.15 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628345 Disease Relevance 1.04 Pain Relevance 1.05

General Comments

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