INT259092

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 4.58
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TSC1) nucleus (TCEAL1) embryo development (TSC1)
protein complex (TSC1) cytoplasm (TSC1)
Anatomy Link Frequency
lung 4
liver 1
skin 1
TSC1 (Homo sapiens)
TCEAL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 114 100.00 Very High Very High Very High
Breast Cancer 30 91.12 High High
Carcinoma 66 89.96 High High
Adenoma 45 82.00 Quite High
Ductal Carcinoma 54 81.64 Quite High
Malignant Neoplastic Disease 33 80.40 Quite High
Pancreatic Cancer 111 79.00 Quite High
Apoptosis 6 16.48 Low Low
Adenocarcinoma 9 5.00 Very Low Very Low Very Low
Cleidocranial Dysplasia 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the human LMO4 gene is located on chromosome 1p22.3 [35], which is a region deleted in several human cancers, such as those of liver, skin, and lung [36,37], and Setogawa et al reported that the tumor suppressor LKB1 induces p21 expression in collaboration with LMO4, suggesting that LMO4 may have a tumor suppressor function [34].
tumor suppressor Positive_regulation (induces) of Gene_expression (expression) of p21 in lung associated with cancer
1) Confidence 0.01 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.53 Pain Relevance 0
However, the human LMO4 gene is located on chromosome 1p22.3 [35], which is a region deleted in several human cancers, such as those of liver, skin, and lung [36,37], and Setogawa et al reported that the tumor suppressor LKB1 induces p21 expression in collaboration with LMO4, suggesting that LMO4 may have a tumor suppressor function [34].
tumor suppressor Positive_regulation (induces) of in skin Gene_expression (expression) of p21 in lung associated with cancer
2) Confidence 0.00 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.53 Pain Relevance 0
However, the human LMO4 gene is located on chromosome 1p22.3 [35], which is a region deleted in several human cancers, such as those of liver, skin, and lung [36,37], and Setogawa et al reported that the tumor suppressor LKB1 induces p21 expression in collaboration with LMO4, suggesting that LMO4 may have a tumor suppressor function [34].
tumor suppressor Positive_regulation (induces) of in liver Gene_expression (expression) of p21 in lung associated with cancer
3) Confidence 0.00 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.53 Pain Relevance 0

General Comments

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