INT259094

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Context Info
Confidence 0.18
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 5.50
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (STK11, TCEAL1) cytosol (STK11) mitochondrion (STK11)
small molecule metabolic process (STK11) cell cycle (STK11) protein complex (STK11)
Anatomy Link Frequency
lung 4
liver 1
skin 1
STK11 (Homo sapiens)
TCEAL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 152 99.76 Very High Very High Very High
Pancreatic Cancer 148 99.20 Very High Very High Very High
Syndrome 4 97.04 Very High Very High Very High
Breast Cancer 40 90.44 High High
Carcinoma 88 89.28 High High
Adenoma 60 81.32 Quite High
Ductal Carcinoma 72 80.96 Quite High
Malignant Neoplastic Disease 44 80.40 Quite High
Apoptosis 8 16.48 Low Low
Adenocarcinoma 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the human LMO4 gene is located on chromosome 1p22.3 [35], which is a region deleted in several human cancers, such as those of liver, skin, and lung [36,37], and Setogawa et al reported that the tumor suppressor LKB1 induces p21 expression in collaboration with LMO4, suggesting that LMO4 may have a tumor suppressor function [34].
LKB1 Positive_regulation (induces) of Gene_expression (expression) of p21 in lung associated with cancer
1) Confidence 0.18 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.52 Pain Relevance 0
Recently, LKB1 was reported to induce p21 expression in collaboration with LMO4 [34].
LKB1 Positive_regulation (induce) of Gene_expression (expression) of p21
2) Confidence 0.12 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 0.94 Pain Relevance 0
However, the human LMO4 gene is located on chromosome 1p22.3 [35], which is a region deleted in several human cancers, such as those of liver, skin, and lung [36,37], and Setogawa et al reported that the tumor suppressor LKB1 induces p21 expression in collaboration with LMO4, suggesting that LMO4 may have a tumor suppressor function [34].
LKB1 Positive_regulation (induces) of in skin Gene_expression (expression) of p21 in lung associated with cancer
3) Confidence 0.06 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.52 Pain Relevance 0
However, the human LMO4 gene is located on chromosome 1p22.3 [35], which is a region deleted in several human cancers, such as those of liver, skin, and lung [36,37], and Setogawa et al reported that the tumor suppressor LKB1 induces p21 expression in collaboration with LMO4, suggesting that LMO4 may have a tumor suppressor function [34].
LKB1 Positive_regulation (induces) of in liver Gene_expression (expression) of p21 in lung associated with cancer
4) Confidence 0.06 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.52 Pain Relevance 0

General Comments

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