INT259111

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Context Info
Confidence 0.72
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 14
Disease Relevance 12.56
Pain Relevance 0.16

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transcription factor binding (LMO4)
Anatomy Link Frequency
epithelial cell 2
fibroblasts 2
LMO4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 14 85.16 High High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 518 99.84 Very High Very High Very High
Malignant Neoplastic Disease 154 99.68 Very High Very High Very High
Cancer 532 99.48 Very High Very High Very High
Ductal Carcinoma 252 98.70 Very High Very High Very High
Papillomavirus Infection 14 94.68 High High
Carcinoma 308 94.40 High High
Adenoma 210 93.92 High High
Breast Cancer 140 91.28 High High
Adenocarcinoma 42 86.32 High High
Apoptosis 28 85.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expressions of LMO4 mRNA were normalized to that of 18S rRNA.


Transcription (Expressions) of LMO4
1) Confidence 0.72 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 0.46 Pain Relevance 0
However, all IDC cells microdissected from cancer tissues showed relatively high expression of LMO4 mRNA although the sample number was small.
Transcription (expression) of LMO4 associated with ductal carcinoma and cancer
2) Confidence 0.72 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.23 Pain Relevance 0
We investigated LMO4 mRNA expression in 14 pancreatic cancer cell lines, HPDE, a normal pancreatic ductal cell line immortalized by transduction with the E6/E7 genes of human papillomavirus 16 [29,30], and 6 primary cultures of pancreatic fibroblasts derived from resected pancreatic tumors.
Spec (investigated) Transcription (expression) of LMO4 in fibroblasts associated with papillomavirus infection and pancreatic cancer
3) Confidence 0.72 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 0.74 Pain Relevance 0
The level of LMO4 mRNA expression was calculated from a standard curve constructed with total RNA from the SUIT-2 pancreatic cancer cell line.
Transcription (expression) of LMO4 associated with pancreatic cancer
4) Confidence 0.72 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 0.15 Pain Relevance 0
To determine whether LMO4 is correlated with pancreatic cancer and carcinogenesis, we quantified LMO4 mRNA levels in cultured pancreatic cell lines, bulk tissues and microdissection-based target cells (including normal pancreatic ductal, PanIN-1B and PanIN-2, IDC, IPMA, IPMB and IPMC cells), by quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR).
Transcription (levels) of LMO4 associated with adenoma, ductal carcinoma, pancreatic cancer and carcinoma
5) Confidence 0.72 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.38 Pain Relevance 0
Microdissection-based quantitative analysis of LMO4 mRNA
Transcription (analysis) of LMO4
6) Confidence 0.69 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 0.49 Pain Relevance 0
By contrast, there was no significant correlation between LKB1 and LMO4 mRNA levels in cultured cancer cell lines (n = 14, spearman test, p = 0.33; Figure 7a bottom).
Transcription (levels) of LMO4 associated with cancer
7) Confidence 0.53 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 0.77 Pain Relevance 0
There was a significant correlation between LKB1 and LMO4 mRNA levels in non-malignant cells, including normal pancreatic ductal epithelia and PanIN-1B cells (n = 20, p = 0.042, Figure 7b middle), but no significant correlation in IDC cells (n = 8, p = 0.45, Figure 7b bottom).


Transcription (levels) of LMO4 associated with ductal carcinoma and malignant neoplastic disease
8) Confidence 0.53 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 0.88 Pain Relevance 0
9 of 14 pancreatic cancer cell lines expressed higher levels of LMO4 mRNA than did the human pancreatic ductal epithelial cell line (HPDE).
Transcription (expressed) of LMO4 in epithelial cell associated with pancreatic cancer
9) Confidence 0.53 Published 2008 Journal Mol Cancer Section Abstract Doc Link PMC2628350 Disease Relevance 0.98 Pain Relevance 0
The mean LMO4 mRNA level in pancreatic cancer tissues was eight-fold higher than that in non-neoplastic tissues (p < 0.0001) and three-fold higher than that in non-malignant IPMN tissues (p < 0.0001).
Transcription (level) of LMO4 associated with malignant neoplastic disease, cancer and pancreatic cancer
10) Confidence 0.53 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.52 Pain Relevance 0.09
We measured LMO4 mRNA levels in cultured cells, pancreatic bulk tissues and microdissected target cells (normal ductal cells; pancreatic intraepithelial neoplasia-1B [PanIN-1B] cells; PanIN-2 cells; invasive ductal carcinoma [IDC] cells; intraductal papillary-mucinous adenoma [IPMA] cells; IPM borderline [IPMB] cells; and invasive and non-invasive IPM carcinoma [IPMC]) by quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR).


Transcription (levels) of LMO4 associated with adenoma, ductal carcinoma, cancer and carcinoma
11) Confidence 0.53 Published 2008 Journal Mol Cancer Section Abstract Doc Link PMC2628350 Disease Relevance 0.70 Pain Relevance 0
The mean LMO4 mRNA level in non-malignant IPMN tissues was 2.7-fold higher than that in non-neoplastic tissues, although the difference was not statistically significant (p = 0.053).
Transcription (level) of LMO4 associated with malignant neoplastic disease and cancer
12) Confidence 0.53 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.51 Pain Relevance 0.08
9 of 14 pancreatic cancer cell lines expressed higher levels of LMO4 mRNA than did the human pancreatic ductal epithelial cell line (HPDE).
Transcription (levels) of LMO4 in epithelial cell associated with pancreatic cancer
13) Confidence 0.53 Published 2008 Journal Mol Cancer Section Abstract Doc Link PMC2628350 Disease Relevance 0.98 Pain Relevance 0
In the analysis of cultured cells, we found significant correlation between LKB1 and LMO4 mRNA levels in primary cultured fibroblasts (n = 6, spearman test, p = 0.024; Figure 7a, top).
Transcription (levels) of LMO4 in fibroblasts
14) Confidence 0.53 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 0.77 Pain Relevance 0

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