INT259117

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Context Info
Confidence 0.70
First Reported 2008
Last Reported 2008
Negated 3
Speculated 0
Reported most in Body
Documents 1
Total Number 15
Disease Relevance 16.10
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transcription factor binding (LMO4)
Anatomy Link Frequency
fibroblasts 4
LMO4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 15 68.16 Quite High
Disease Link Frequency Relevance Heat
Carcinoma 330 99.86 Very High Very High Very High
Pancreatic Cancer 555 99.84 Very High Very High Very High
Breast Cancer 150 99.80 Very High Very High Very High
Malignant Neoplastic Disease 165 99.44 Very High Very High Very High
Cancer 570 99.04 Very High Very High Very High
Ductal Carcinoma 270 97.56 Very High Very High Very High
Hyperplasia 15 97.12 Very High Very High Very High
Adenoma 225 96.76 Very High Very High Very High
Papillomavirus Infection 15 93.36 High High
Apoptosis 30 92.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All data from bulk tissue analyses indicated that LMO4 was overexpressed in pancreatic cancer.


Positive_regulation (overexpressed) of Gene_expression (overexpressed) of LMO4 associated with pancreatic cancer
1) Confidence 0.70 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.47 Pain Relevance 0.07
In 2005, Sum and colleagues reported that LMO4 mRNA was overexpressed in 5 of 10 human breast cancer cell lines; in situ hybridization analysis of 177 primary invasive breast carcinomas revealed overexpression of LMO4 in 56% of the specimens [20].
Positive_regulation (overexpression) of Gene_expression (overexpression) of LMO4 associated with breast cancer
2) Confidence 0.70 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.12 Pain Relevance 0
As shown in Figure 3, 9 of the 14 pancreatic cancer cell lines expressed higher levels of LMO4 than did HPDE.
Positive_regulation (levels) of Gene_expression (expressed) of LMO4 associated with pancreatic cancer
3) Confidence 0.70 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 0.73 Pain Relevance 0
In conclusion, the present results showed that LMO4 is overexpressed in pancreatic cancer related to both the PanIN-conventional IDC pathway and the IPMA-IPMC pathway, but not at the early stages of pancreatic carcinogenesis.


Positive_regulation (overexpressed) of Neg (not) Gene_expression (overexpressed) of LMO4 associated with adenoma, ductal carcinoma, pancreatic cancer and carcinoma
4) Confidence 0.70 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.01 Pain Relevance 0
These data suggested that LMO4 is overexpressed in pancreatic cancer, especially in the invasive step of cancer, but not in the early stage of pancreatic carcinogenesis.


Neg (not) Positive_regulation (overexpressed) of Neg (not) Gene_expression (overexpressed) of LMO4 associated with cancer and pancreatic cancer
5) Confidence 0.70 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.07 Pain Relevance 0
In the present study, LMO4 mRNA was not overexpressed in any of the 14 pancreatic cancer cell lines.
Neg (not) Positive_regulation (overexpressed) of Neg (not) Gene_expression (overexpressed) of LMO4 associated with pancreatic cancer
6) Confidence 0.50 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.24 Pain Relevance 0
Four pancreatic cancer cell lines, Hs766T, AsPC-1, KP-2 and KP-3, expressed higher levels of LMO4 than did any of the primary cultures of pancreatic fibroblasts.
Positive_regulation (levels) of Gene_expression (expressed) of LMO4 in fibroblasts associated with pancreatic cancer
7) Confidence 0.50 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 0.92 Pain Relevance 0.06
In 2005, Sum and colleagues reported that LMO4 mRNA was overexpressed in 5 of 10 human breast cancer cell lines; in situ hybridization analysis of 177 primary invasive breast carcinomas revealed overexpression of LMO4 in 56% of the specimens [20].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of LMO4 associated with breast cancer
8) Confidence 0.50 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.02 Pain Relevance 0
These results suggested that LMO4 is overexpressed at late stages in carcinogenesis of pancreatic cancer.



Positive_regulation (overexpressed) of Gene_expression (overexpressed) of LMO4 associated with pancreatic cancer
9) Confidence 0.47 Published 2008 Journal Mol Cancer Section Abstract Doc Link PMC2628350 Disease Relevance 0.71 Pain Relevance 0
We also found that both invasive and non-invasive IPMC cells expressed higher levels of LMO4 than did non-malignant IPMN or normal ductal cells.
Positive_regulation (levels) of Gene_expression (expressed) of LMO4 associated with malignant neoplastic disease, cancer and carcinoma
10) Confidence 0.47 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.59 Pain Relevance 0
IPMC cells expressed significantly higher levels of LMO4 than did normal ductal epithelia (p < 0.001), IPMA (p < 0.001) and IPMB cells (p = 0.003).


Positive_regulation (levels) of Gene_expression (expressed) of LMO4
11) Confidence 0.47 Published 2008 Journal Mol Cancer Section Abstract Doc Link PMC2628350 Disease Relevance 0.83 Pain Relevance 0
IDC cells expressed significantly higher levels of LMO4 than did normal ductal epithelia or PanIN-1B cells (p < 0.001 for both) or PanIN-2 cells (p = 0.014).
Positive_regulation (levels) of Gene_expression (expressed) of LMO4
12) Confidence 0.47 Published 2008 Journal Mol Cancer Section Abstract Doc Link PMC2628350 Disease Relevance 0.93 Pain Relevance 0
Bulk tissue analysis showed that pancreatic cancer tissues expressed higher levels of LMO4 than non-neoplastic and non-malignant IPMN tissues; however, the difference in LMO4 expression between non-neoplastic tissues and non-malignant IPMN was not significant.
Positive_regulation (levels) of Gene_expression (expressed) of LMO4 associated with malignant neoplastic disease, cancer and pancreatic cancer
13) Confidence 0.47 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.18 Pain Relevance 0
Our goal was to characterize LMO4 expression in the early and late stages of pancreatic carcinogenesis to clarify both if and when overexpression of LMO4 occurs.


Positive_regulation (overexpression) of Gene_expression (overexpression) of LMO4
14) Confidence 0.47 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.19 Pain Relevance 0
Analyses of cultured cells revealed that 9 of 14 pancreatic cancer cell lines and all primary cultures of pancreatic fibroblasts expressed higher levels of LMO4 than did a non-neoplastic pancreatic ductal cell line.
Positive_regulation (levels) of Gene_expression (expressed) of LMO4 in fibroblasts associated with pancreatic cancer
15) Confidence 0.47 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.10 Pain Relevance 0

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