INT259118

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Context Info
Confidence 0.70
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 10
Disease Relevance 9.69
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transcription factor binding (LMO4)
Anatomy Link Frequency
fibroblasts 2
LMO4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 10 60.00 Quite High
Disease Link Frequency Relevance Heat
Carcinoma 220 99.52 Very High Very High Very High
Pancreatic Cancer 370 99.48 Very High Very High Very High
Malignant Neoplastic Disease 110 99.44 Very High Very High Very High
Breast Cancer 100 99.28 Very High Very High Very High
Ductal Carcinoma 180 99.24 Very High Very High Very High
Cancer 380 99.04 Very High Very High Very High
Hyperplasia 10 97.12 Very High Very High Very High
Adenoma 150 93.52 High High
Papillomavirus Infection 10 92.68 High High
Metastasis 10 80.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Figure 3, 9 of the 14 pancreatic cancer cell lines expressed higher levels of LMO4 than did HPDE.
Positive_regulation (levels) of LMO4 associated with pancreatic cancer
1) Confidence 0.70 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 0.73 Pain Relevance 0
Four pancreatic cancer cell lines, Hs766T, AsPC-1, KP-2 and KP-3, expressed higher levels of LMO4 than did any of the primary cultures of pancreatic fibroblasts.
Positive_regulation (levels) of LMO4 in fibroblasts associated with pancreatic cancer
2) Confidence 0.70 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 0.92 Pain Relevance 0.06
IPMC cells expressed significantly higher levels of LMO4 than did normal ductal epithelia (p < 0.001), IPMA (p < 0.001) and IPMB cells (p = 0.003).


Positive_regulation (levels) of LMO4
3) Confidence 0.47 Published 2008 Journal Mol Cancer Section Abstract Doc Link PMC2628350 Disease Relevance 0.82 Pain Relevance 0
IDC cells expressed significantly higher levels of LMO4 than did normal ductal epithelia or PanIN-1B cells (p < 0.001 for both) or PanIN-2 cells (p = 0.014).
Positive_regulation (levels) of LMO4
4) Confidence 0.47 Published 2008 Journal Mol Cancer Section Abstract Doc Link PMC2628350 Disease Relevance 0.87 Pain Relevance 0
In 2005, Sum and colleagues reported that LMO4 mRNA was overexpressed in 5 of 10 human breast cancer cell lines; in situ hybridization analysis of 177 primary invasive breast carcinomas revealed overexpression of LMO4 in 56% of the specimens [20].
Positive_regulation (overexpressed) of LMO4 associated with breast cancer
5) Confidence 0.47 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.02 Pain Relevance 0
Pancreatic carcinomas (both IDC and IPMC) expressed significantly higher levels of LMO4 mRNA than did normal ductal epithelia, PanIN-1B, PanIN-2, IPMA and IPMB.
Positive_regulation (levels) of LMO4 associated with pancreatic cancer
6) Confidence 0.47 Published 2008 Journal Mol Cancer Section Abstract Doc Link PMC2628350 Disease Relevance 0.70 Pain Relevance 0
We also found that both invasive and non-invasive IPMC cells expressed higher levels of LMO4 than did non-malignant IPMN or normal ductal cells.
Positive_regulation (levels) of LMO4 associated with malignant neoplastic disease, cancer and carcinoma
7) Confidence 0.47 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.58 Pain Relevance 0
Analyses of cultured cells revealed that 9 of 14 pancreatic cancer cell lines and all primary cultures of pancreatic fibroblasts expressed higher levels of LMO4 than did a non-neoplastic pancreatic ductal cell line.
Positive_regulation (levels) of LMO4 in fibroblasts associated with pancreatic cancer
8) Confidence 0.47 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.10 Pain Relevance 0
Bulk tissue analysis showed that pancreatic cancer tissues expressed higher levels of LMO4 than non-neoplastic and non-malignant IPMN tissues; however, the difference in LMO4 expression between non-neoplastic tissues and non-malignant IPMN was not significant.
Positive_regulation (levels) of LMO4 associated with malignant neoplastic disease, cancer and pancreatic cancer
9) Confidence 0.47 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.17 Pain Relevance 0
As shown in Figure 5, IDC cells expressed significantly higher levels of LMO4 than did normal ductal epithelial or PanIN-1B cells (p < 0.0001 for both) or PanIN-2 cells (p = 0.014).
Positive_regulation (levels) of LMO4 associated with ductal carcinoma
10) Confidence 0.47 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 0.79 Pain Relevance 0

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