INT259138

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.39
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (DSG2) plasma membrane (DSG2)
Anatomy Link Frequency
cleavage 2
DSG2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 30 97.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adenocarcinoma 28 99.40 Very High Very High Very High
Pancreatitis 34 97.76 Very High Very High Very High
Pancreatic Cancer 76 85.52 High High
Disease 4 84.52 Quite High
Cancer 40 60.44 Quite High
Adhesions 24 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 12 5.00 Very Low Very Low Very Low
Metastasis 6 5.00 Very Low Very Low Very Low
Stomach Cancer 4 5.00 Very Low Very Low Very Low
Skin Cancer 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether hK7 could participate in decreasing the levels of Dsg1 and Dsg2 through proteolytic cleavage, in vitro degradation assays were performed using recombinant hK7 and desmosomal proteins.
Negative_regulation (decreasing) of Gene_expression (levels) of Dsg2 in cleavage
1) Confidence 0.41 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.87 Pain Relevance 0.29
In this report we have shown that the levels of cell-surface resident Dsg1 and Dsg2 are reduced in pancreatic adenocarcinomas compared with normal and chronic pancreatitis tissues.
Negative_regulation (reduced) of Gene_expression (levels) of Dsg2 associated with adenocarcinoma and chronic pancreatitis
2) Confidence 0.41 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.52 Pain Relevance 0.10

General Comments

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