INT259142

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 3.74
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (DSG2) plasma membrane (DSG2)
DSG2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 75 97.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 60 100.00 Very High Very High Very High
Pancreatic Cancer 190 99.90 Very High Very High Very High
Adenocarcinoma 70 99.40 Very High Very High Very High
Cancer 100 98.78 Very High Very High Very High
Pancreatitis 85 97.76 Very High Very High Very High
Malignant Neoplastic Disease 30 5.00 Very Low Very Low Very Low
Metastasis 15 5.00 Very Low Very Low Very Low
Stomach Cancer 10 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
Skin Cancer 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this report we have shown that the levels of cell-surface resident Dsg1 and Dsg2 are reduced in pancreatic adenocarcinomas compared with normal and chronic pancreatitis tissues.
Negative_regulation (reduced) of Dsg2 associated with adenocarcinoma and chronic pancreatitis
1) Confidence 0.41 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.51 Pain Relevance 0.10
The correspondence between increased hK7 expression in pancreatic tumors and loss of Dsg2 is highlighted in the immunohistochemistry studies we have performed.
Negative_regulation (loss) of Dsg2 associated with pancreatic cancer
2) Confidence 0.41 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.87 Pain Relevance 0.20
A reduction in the amount of the cell adhesion components Dsg1 and Dsg2 in pancreatic tumors suggests that loss of these desmosomal proteins may play a role in pancreatic cancer invasion.
Negative_regulation (reduction) of Dsg2 associated with pancreatic cancer and adhesions
3) Confidence 0.41 Published 2008 Journal BMC Cancer Section Abstract Doc Link PMC2628383 Disease Relevance 0.79 Pain Relevance 0.09
The levels of immunoreactive Dsg1 and Dsg2 were reduced in pancreatic adenocarcinomas compared with both normal pancreatic and chronic pancreatitis tissues.
Negative_regulation (reduced) of Dsg2 associated with adenocarcinoma and chronic pancreatitis
4) Confidence 0.41 Published 2008 Journal BMC Cancer Section Abstract Doc Link PMC2628383 Disease Relevance 0.67 Pain Relevance 0.10
For example, the tumor section stained for Dsg2 (Figure 2C, this study), showing a loss of Dsg2 immunoreactivity, is from the same tissue used to demonstrate increased hK7 expression in pancreatic tumors (Figure 2A, ref. [13]).
Negative_regulation (loss) of Dsg2 associated with cancer and pancreatic cancer
5) Confidence 0.41 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.89 Pain Relevance 0.23

General Comments

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