INT259143

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Context Info
Confidence 0.64
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 15
Disease Relevance 11.94
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (KLK7) extracellular region (KLK7)
Anatomy Link Frequency
BxPC-3 8
lung 2
KLK7 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 225 95.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 570 99.92 Very High Very High Very High
Adenocarcinoma 210 99.76 Very High Very High Very High
Cancer 300 99.60 Very High Very High Very High
Ovarian Cancer 15 98.24 Very High Very High Very High
Lung Cancer 15 97.60 Very High Very High Very High
Disease 30 96.88 Very High Very High Very High
Pancreatitis 255 95.36 Very High Very High Very High
Adhesions 180 91.84 High High
Malignant Neoplastic Disease 90 81.28 Quite High
Stomach Cancer 30 80.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, recently we have further demonstrated that KLK7/hK7 is overexpressed in pancreatic adenocarcinomas [13].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of hK7 associated with adenocarcinoma
1) Confidence 0.64 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 1.16 Pain Relevance 0
These findings suggest that decreased levels of desmosomal proteins seen in pancreatic cancer may result from the action of hK7 overexpressed in these tumors.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of hK7 associated with cancer and pancreatic cancer
2) Confidence 0.64 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.50 Pain Relevance 0
Studies have also shown that hK7 is overexpressed in squamous cervical cancerous cells [34], ovarian tumor cells [35,36], cervical adenocarcinomas [37], and in lung cancer [38].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of hK7 in lung associated with adenocarcinoma, lung cancer and ovarian cancer
3) Confidence 0.64 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 1.16 Pain Relevance 0
For example, the tumor section stained for Dsg2 (Figure 2C, this study), showing a loss of Dsg2 immunoreactivity, is from the same tissue used to demonstrate increased hK7 expression in pancreatic tumors (Figure 2A, ref. [13]).
Positive_regulation (increased) of Gene_expression (expression) of hK7 associated with cancer and pancreatic cancer
4) Confidence 0.64 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.87 Pain Relevance 0.23
Moreover, recently we have further demonstrated that KLK7/hK7 is overexpressed in pancreatic adenocarcinomas [13].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of KLK7 associated with adenocarcinoma
5) Confidence 0.46 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 1.16 Pain Relevance 0
BxPC-3 cells stably transfected to overexpress hK7 were used to examine the effect of hK7 on cell-surface resident Dsg2.


Positive_regulation (overexpress) of Gene_expression (overexpress) of hK7 in BxPC-3
6) Confidence 0.43 Published 2008 Journal BMC Cancer Section Abstract Doc Link PMC2628383 Disease Relevance 0.59 Pain Relevance 0.08
Using in vitro degradation assays, both Dsg1 and Dsg2 could be readily proteolyzed by hK7, which is overexpressed in pancreatic adenocarcinomas.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of hK7 associated with adenocarcinoma
7) Confidence 0.43 Published 2008 Journal BMC Cancer Section Abstract Doc Link PMC2628383 Disease Relevance 0.72 Pain Relevance 0.08
However, the effects of hK7 expression on desmosomal proteins in any type of cancer, including pancreatic cancer where overexpression of KLK7/hK7 has been clearly established, have not been studied.
Positive_regulation (overexpression) of Gene_expression (overexpression) of hK7 associated with cancer and pancreatic cancer
8) Confidence 0.43 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 1.19 Pain Relevance 0.08
When hK7 was overexpressed in this cell line, there was a significant increase in the amount of soluble Dsg2 released into the culture medium compared with vector-transfected control cells.


Positive_regulation (overexpressed) of Gene_expression (overexpressed) of hK7
9) Confidence 0.43 Published 2008 Journal BMC Cancer Section Abstract Doc Link PMC2628383 Disease Relevance 0.74 Pain Relevance 0.10
We have also demonstrated that these desmosomal proteins are substrates of the chymotryptic-like protease hK7, which is overexpressed in pancreatic cancer.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of hK7 associated with pancreatic cancer
10) Confidence 0.43 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.47 Pain Relevance 0.10
The enforced expression of hK7 in BxPC-3 cells that express significant amounts of Dsg2 resulted in a marked increase in the shedding of soluble Dsg2, which is consistent with the notion that aberrant expression of hK7 in pancreatic tumors may result in diminished cell-cell adhesion and facilitate tumor cell invasion.



Positive_regulation (enforced) of Gene_expression (expression) of hK7 in BxPC-3 associated with cancer, pancreatic cancer and adhesions
11) Confidence 0.43 Published 2008 Journal BMC Cancer Section Abstract Doc Link PMC2628383 Disease Relevance 0.84 Pain Relevance 0.07
Since BxPC-3 cells do not express hK7, we used these cells to mimic the aberrant expression of KLK7 observed in pancreatic tumors by expressing high levels of hK7 through stable transfection.
Positive_regulation (levels) of Gene_expression (expressing) of hK7 in BxPC-3 associated with pancreatic cancer
12) Confidence 0.43 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.45 Pain Relevance 0
BxPC-3 cells stably transfected to overexpress hK7 were used to examine the effect of hK7 on cell-surface resident Dsg2.


Positive_regulation (transfected) of Gene_expression (overexpress) of hK7 in BxPC-3
13) Confidence 0.43 Published 2008 Journal BMC Cancer Section Abstract Doc Link PMC2628383 Disease Relevance 0.60 Pain Relevance 0.08
In a previous study, we have reported that kallikrein 7 (KLK7/hK7) is overexpressed in pancreatic adenocarcinomas and enhances pancreatic cancer cell invasion by shedding E-cadherin [13].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of kallikrein 7 associated with adenocarcinoma and pancreatic cancer
14) Confidence 0.43 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 1.14 Pain Relevance 0
In a previous report we have demonstrated that the chymotryptic-like serine protease kallikrein 7 (KLK7/hK7) is overexpressed in pancreatic cancer.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of hK7 associated with pancreatic cancer
15) Confidence 0.43 Published 2008 Journal BMC Cancer Section Abstract Doc Link PMC2628383 Disease Relevance 0.33 Pain Relevance 0

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