INT259144

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Context Info
Confidence 0.35
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 3.69
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (DSG2) plasma membrane (DSG2)
Anatomy Link Frequency
germline 1
DSG2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 30 89.68 High High
Inflammation 8 58.92 Quite High
imagery 8 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
nud 4 5.00 Very Low Very Low Very Low
abdominal pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stomach Cancer 256 100.00 Very High Very High Very High
Gastritis 32 100.00 Very High Very High Very High
Infection 16 100.00 Very High Very High Very High
Pancreatic Cancer 76 99.84 Very High Very High Very High
Pancreatitis 34 98.88 Very High Very High Very High
Disease 16 98.48 Very High Very High Very High
Adenocarcinoma 36 97.08 Very High Very High Very High
Carcinoma 74 78.80 Quite High
Metaplasia 8 76.12 Quite High
Cyst 8 71.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
hK7 cleaves both recombinant Dsg1 and Dsg2 in vitro
Dsg2 Binding (recombinant) of
1) Confidence 0.35 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.90 Pain Relevance 0.31
Immunoblotting for Dsg1 and Dsg2 in pancreatic cancer cell lines
Dsg2 Binding (Immunoblotting) of associated with pancreatic cancer
2) Confidence 0.35 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.20 Pain Relevance 0
Although there does not appear to be an association between Helicobacter pylori infection and HDGC, it is important to test for H pylori to document the prevalence of infection in mutation carriers.
HDGC Binding (association) of associated with gastritis, stomach cancer and infection
3) Confidence 0.13 Published 2010 Journal Journal of Medical Genetics Section Body Doc Link PMC2991043 Disease Relevance 0.65 Pain Relevance 0
These centres could also hold a collection of gastrectomy specimens obtained from individuals with HDGC, since these are a valuable learning resource.


HDGC Binding (individuals) of associated with stomach cancer
4) Confidence 0.11 Published 2010 Journal Journal of Medical Genetics Section Body Doc Link PMC2991043 Disease Relevance 0.50 Pain Relevance 0
Additionally, a critical question that remains unanswered is how long early lesions of HDGC can remain indolent until there is emergence of clinical disease that may be rapidly progressive and lethal.
HDGC Binding (indolent) of associated with disease and stomach cancer
5) Confidence 0.11 Published 2010 Journal Journal of Medical Genetics Section Body Doc Link PMC2991043 Disease Relevance 1.07 Pain Relevance 0.03
By genetic criteria, any family with a germline CDH1 mutation would comprise an HDGC kindred.
HDGC Binding (kindred) of in germline associated with stomach cancer
6) Confidence 0.10 Published 2010 Journal Journal of Medical Genetics Section Body Doc Link PMC2991043 Disease Relevance 0.38 Pain Relevance 0

General Comments

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