INT259145

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.53
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (DSG2) plasma membrane (DSG2)
Anatomy Link Frequency
BxPC-3 1
DSG2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 30 92.60 High High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 76 97.08 Very High Very High Very High
Adenocarcinoma 28 95.56 Very High Very High Very High
Adhesions 24 94.96 High High
Cancer 40 94.00 High High
Pancreatitis 34 92.60 High High
Malignant Neoplastic Disease 12 5.00 Very Low Very Low Very Low
Metastasis 6 5.00 Very Low Very Low Very Low
Stomach Cancer 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Skin Cancer 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When hK7 was overexpressed in this cell line, there was a significant increase in the amount of soluble Dsg2 released into the culture medium compared with vector-transfected control cells.


Positive_regulation (increase) of Dsg2
1) Confidence 0.44 Published 2008 Journal BMC Cancer Section Abstract Doc Link PMC2628383 Disease Relevance 0.70 Pain Relevance 0.09
The enforced expression of hK7 in BxPC-3 cells that express significant amounts of Dsg2 resulted in a marked increase in the shedding of soluble Dsg2, which is consistent with the notion that aberrant expression of hK7 in pancreatic tumors may result in diminished cell-cell adhesion and facilitate tumor cell invasion.



Positive_regulation (increase) of Dsg2 in BxPC-3 associated with cancer, pancreatic cancer and adhesions
2) Confidence 0.44 Published 2008 Journal BMC Cancer Section Abstract Doc Link PMC2628383 Disease Relevance 0.83 Pain Relevance 0.07

General Comments

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