INT259149

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Context Info
Confidence 0.74
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 13
Total Number 16
Disease Relevance 9.73
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (DSG2) plasma membrane (DSG2)
Anatomy Link Frequency
BxPC-3 6
germline 1
cleavage 1
DSG2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 195 97.28 Very High Very High Very High
Inflammation 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
nud 3 5.00 Very Low Very Low Very Low
abdominal pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 494 100.00 Very High Very High Very High
Stomach Cancer 215 100.00 Very High Very High Very High
Infection 12 100.00 Very High Very High Very High
Gastritis 24 99.98 Very High Very High Very High
Adenocarcinoma 188 98.92 Very High Very High Very High
Cancer 311 97.60 Very High Very High Very High
Pancreatitis 221 97.28 Very High Very High Very High
Skin Cancer 26 96.24 Very High Very High Very High
Carcinoma 67 93.08 High High
Adhesions 156 92.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Due to the significant expression of Dsg2 in BxPC-3 cell lysates, immunocytochemical staining was performed on intact cells to determine its cellular localization and distribution.
Gene_expression (expression) of Dsg2 in BxPC-3
1) Confidence 0.74 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.24 Pain Relevance 0
This revealed that only Dsg2 was expressed in appreciable levels in BxPC-3 cells.
Gene_expression (expressed) of Dsg2 in BxPC-3
2) Confidence 0.74 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.27 Pain Relevance 0
Dsg1 was not detected in either of the cell lines (Fig. 4A, lanes 1 and 2), whereas Dsg2 was readily detected in BxPC-3 but not Panc-1 cell lysates (Fig. 4A, lanes 3 and 4, respectively).
Gene_expression (detected) of Dsg2 in BxPC-3
3) Confidence 0.74 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.24 Pain Relevance 0
For example, Dsg2 is ubiquitously expressed in all tissues containing desmosomes [40], whereas Dsg1 and Dsg3 are mainly restricted to stratified squamous epithelia [41].
Gene_expression (expressed) of Dsg2
4) Confidence 0.64 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.75 Pain Relevance 0
Desmosomal constituents, like Dsg2, have been demonstrated to be expressed abnormally in gastric cancer [30] and its decreased expression has been associated with poorer prognosis for diffuse-type gastric cancer [31].
Gene_expression (expressed) of Dsg2 associated with stomach cancer
5) Confidence 0.64 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 1.03 Pain Relevance 0
The expression of Dsg1, Dsg2, and Dsg3 in pancreatic tissues was examined by immunohistochemistry and their expression in two pancreatic cancer cell lines, BxPC-3 and Panc-1, was determined by western blot analysis.
Spec (examined) Gene_expression (expression) of Dsg2 in BxPC-3 associated with pancreatic cancer
6) Confidence 0.57 Published 2008 Journal BMC Cancer Section Abstract Doc Link PMC2628383 Disease Relevance 0.48 Pain Relevance 0.06
To determine whether hK7 could participate in decreasing the levels of Dsg1 and Dsg2 through proteolytic cleavage, in vitro degradation assays were performed using recombinant hK7 and desmosomal proteins.
Gene_expression (levels) of Dsg2 in cleavage
7) Confidence 0.57 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.86 Pain Relevance 0.29
To identify pancreatic cancer cell lines that could be used to examine hK7-dependent cleavage of desmosomal proteins in a cell-based system, cell lysates were prepared from Panc-1 and BxPC-3 cell lines and assessed for the levels of Dsg1 and Dsg2 by western blot analysis.
Gene_expression (levels) of Dsg2 in BxPC-3 associated with pancreatic cancer
8) Confidence 0.57 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.24 Pain Relevance 0
In this report we have shown that the levels of cell-surface resident Dsg1 and Dsg2 are reduced in pancreatic adenocarcinomas compared with normal and chronic pancreatitis tissues.
Gene_expression (levels) of Dsg2 associated with adenocarcinoma and chronic pancreatitis
9) Confidence 0.57 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.52 Pain Relevance 0.10
The correspondence between increased hK7 expression in pancreatic tumors and loss of Dsg2 is highlighted in the immunohistochemistry studies we have performed.
Gene_expression (expression) of Dsg2 associated with pancreatic cancer
10) Confidence 0.57 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.88 Pain Relevance 0.21
In cell-based assays where both E-cadherin and desmogleins (Dsg2) are present, we can not dissect whether the action of hK7 upon a particular substrate is a primary or secondary effect, or whether both substrates are acted upon concurrently.
Gene_expression (present) of Dsg2
11) Confidence 0.57 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.36 Pain Relevance 0
The levels of immunoreactive Dsg1 and Dsg2 were reduced in pancreatic adenocarcinomas compared with both normal pancreatic and chronic pancreatitis tissues.
Gene_expression (levels) of Dsg2 associated with adenocarcinoma and chronic pancreatitis
12) Confidence 0.57 Published 2008 Journal BMC Cancer Section Abstract Doc Link PMC2628383 Disease Relevance 0.67 Pain Relevance 0.10
The enforced expression of hK7 in BxPC-3 cells that express significant amounts of Dsg2 resulted in a marked increase in the shedding of soluble Dsg2, which is consistent with the notion that aberrant expression of hK7 in pancreatic tumors may result in diminished cell-cell adhesion and facilitate tumor cell invasion.



Gene_expression (express) of Dsg2 in BxPC-3 associated with cancer, pancreatic cancer and adhesions
13) Confidence 0.57 Published 2008 Journal BMC Cancer Section Abstract Doc Link PMC2628383 Disease Relevance 0.84 Pain Relevance 0.07
The management for those with clinical features suggestive of HDGC but without a germline CDH1 mutation is not straightforward.
Gene_expression (mutation) of HDGC in germline associated with stomach cancer
14) Confidence 0.18 Published 2010 Journal Journal of Medical Genetics Section Body Doc Link PMC2991043 Disease Relevance 0.75 Pain Relevance 0
Increasing awareness of HDGC and the rapid advances in genetic diagnostic tools, endoscopic modalities and the increasing use of laparoscopic surgery led a group of clinical geneticists, gastroenterologists, surgeons, oncologists, pathologists and molecular biologists from nine different countries to convene a workshop in order to update the management guidelines for this condition originally set in 1999 and to propose directions for future research.
Gene_expression (awareness) of HDGC associated with stomach cancer
15) Confidence 0.18 Published 2010 Journal Journal of Medical Genetics Section Body Doc Link PMC2991043 Disease Relevance 0.95 Pain Relevance 0
Although there does not appear to be an association between Helicobacter pylori infection and HDGC, it is important to test for H pylori to document the prevalence of infection in mutation carriers.
Gene_expression (infection) of HDGC associated with gastritis, stomach cancer and infection
16) Confidence 0.18 Published 2010 Journal Journal of Medical Genetics Section Body Doc Link PMC2991043 Disease Relevance 0.65 Pain Relevance 0

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