INT259151

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Context Info
Confidence 0.95
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 2.74
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (DSG2) plasma membrane (DSG2)
Anatomy Link Frequency
cleavage 3
DSG2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 90 90.20 High High
Disease Link Frequency Relevance Heat
Pancreatitis 102 99.40 Very High Very High Very High
Adenocarcinoma 84 97.60 Very High Very High Very High
Pancreatic Cancer 228 96.20 Very High Very High Very High
Disease 12 88.28 High High
Adhesions 72 59.92 Quite High
Malignant Neoplastic Disease 36 58.40 Quite High
Cancer 120 41.04 Quite Low
Metastasis 18 5.00 Very Low Very Low Very Low
Stomach Cancer 12 5.00 Very Low Very Low Very Low
Skin Cancer 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recombinant Dsg2 was also cleaved by hK7 in a time-dependent manner, however, in contrast to the complete proteolysis of Dsg1, the cleavage of Dsg2 resulted in distinct proteolytic fragments (Fig. 3B, left).
Protein_catabolism (cleaved) of Dsg2 in cleavage
1) Confidence 0.95 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.67 Pain Relevance 0.19
In support of an association between hK7 and the desmogleins, hK7 was able to proteolyze both Dsg1 and Dsg2.
Protein_catabolism (proteolyze) of Dsg2
2) Confidence 0.95 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.23 Pain Relevance 0
Interestingly, incubation of Dsg2 with hK7 resulted in cleavage of Dsg2 into distinct fragments rather than indiscriminant degradation.
Protein_catabolism (cleavage) of Dsg2 in cleavage
3) Confidence 0.84 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.24 Pain Relevance 0
The ability of hK7 to degrade Dsg1 and Dsg2 was investigated using in vitro degradation assays.
Protein_catabolism (degrade) of Dsg2
4) Confidence 0.62 Published 2008 Journal BMC Cancer Section Abstract Doc Link PMC2628383 Disease Relevance 0.49 Pain Relevance 0.08
To examine the cleavage of Dsg2 from the cell surface in the presence of hK7, concentrated conditioned medium from hK7-expressing and vector-transfected control cells was prepared and the level of soluble Dsg2 was determined by western blot.
Spec (examine) Protein_catabolism (cleavage) of Dsg2 in cleavage
5) Confidence 0.62 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.19 Pain Relevance 0
hK7 cleaves both recombinant Dsg1 and Dsg2 in vitro
Protein_catabolism (cleaves) of Dsg2
6) Confidence 0.27 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.91 Pain Relevance 0.31

General Comments

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