INT259152

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Context Info
Confidence 0.48
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.60
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DSG1) plasma membrane (DSG1)
Anatomy Link Frequency
cleavage 2
DSG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 45 78.76 Quite High
Disease Link Frequency Relevance Heat
Pancreatitis 51 87.96 High High
Adenocarcinoma 42 86.16 High High
Pancreatic Cancer 114 77.84 Quite High
Disease 6 76.84 Quite High
Malignant Neoplastic Disease 18 56.36 Quite High
Cancer 60 6.08 Low Low
Adhesions 36 5.00 Very Low Very Low Very Low
Metastasis 9 5.00 Very Low Very Low Very Low
Stomach Cancer 6 5.00 Very Low Very Low Very Low
Skin Cancer 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upon incubation with thermolysin-activated hK7, recombinant Dsg1 was rapidly degraded with little detectable protein remaining after 60 minutes (Fig. 3A, left).
Positive_regulation (activated) of Neg (little) Protein_catabolism (degraded) of Dsg1
1) Confidence 0.48 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.78 Pain Relevance 0.26
Recombinant Dsg2 was also cleaved by hK7 in a time-dependent manner, however, in contrast to the complete proteolysis of Dsg1, the cleavage of Dsg2 resulted in distinct proteolytic fragments (Fig. 3B, left).
Positive_regulation (resulted) of Protein_catabolism (proteolysis) of Dsg1 in cleavage
2) Confidence 0.48 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.59 Pain Relevance 0.18
Proteolysis of Dsg1 resulted in a rapid degradation of recombinant Dsg1 into fragments undetectable by western blot.
Positive_regulation (resulted) of Protein_catabolism (degradation) of Dsg1
3) Confidence 0.45 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.23 Pain Relevance 0

General Comments

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