INT259164

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.00
Pain Relevance 1.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Gria2) plasma membrane (Gria2) protein complex (Gria2)
Anatomy Link Frequency
neurons 2
cortex 2
dorsal horn 2
Gria2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 78 100.00 Very High Very High Very High
Eae 87 98.72 Very High Very High Very High
Dorsal horn neuron 39 98.68 Very High Very High Very High
Kinase C 3 97.88 Very High Very High Very High
Dorsal horn 63 94.40 High High
Spinal cord 63 92.04 High High
long-term potentiation 9 90.04 High High
central sensitization 12 87.68 High High
antagonist 81 74.40 Quite High
Somatosensory cortex 5 73.92 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 78 100.00 Very High Very High Very High
Inflammatory Pain 84 98.72 Very High Very High Very High
Hypersensitivity 48 95.12 Very High Very High Very High
Pain 21 72.32 Quite High
Hyperalgesia 3 71.88 Quite High
Depression 1 61.84 Quite High
Nociception 30 59.44 Quite High
Injury 5 50.00 Quite Low
Nervous System Injury 12 40.80 Quite Low
Syndrome 3 39.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Such a mechanism might also contribute to CFA-induced internalization of GluR2 subunits in vivo.
Positive_regulation (induced) of GluR2 Binding (internalization) of
1) Confidence 0.40 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.46 Pain Relevance 0.49
In addition, we show that CFA-induced peripheral inflammation leads to GluR2 internalization and GluR1 membrane insertion in dorsal horn neurons, without altering the expression and distribution of total GluR1 and GluR2 proteins in dorsal horn.
Positive_regulation (induced) of GluR2 Binding (internalization) of in dorsal horn associated with inflammation, dorsal horn and dorsal horn neuron
2) Confidence 0.35 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 1.02 Pain Relevance 0.80
Similarly, Protein kinase C phosphorylation of GluR2 at Ser880 disrupts GluR2 binding to its synaptic anchoring protein ABP/GRIP and promotes GluR2 internalization in cultured hippocampal neurons [36,37].
Positive_regulation (promotes) of GluR2 Binding (internalization) of in neurons associated with kinase c
3) Confidence 0.35 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.45 Pain Relevance 0.47
The increase in Glur1 staining intensity and concomitant decrease in GluR2/3 staining intensity found here in deprived cortex 1?
Positive_regulation (increase) of GluR2 Binding (intensity) of in cortex
4) Confidence 0.10 Published 2008 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2638550 Disease Relevance 0.06 Pain Relevance 0.16

General Comments

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