INT259166

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Context Info
Confidence 0.70
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.47
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Gria2) plasma membrane (Gria2) protein complex (Gria2)
Anatomy Link Frequency
neurons 1
Gria2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn neuron 13 99.12 Very High Very High Very High
Inflammation 26 99.04 Very High Very High Very High
Eae 29 95.72 Very High Very High Very High
Dorsal horn 21 94.28 High High
Spinal cord 21 53.00 Quite High
antagonist 28 32.48 Quite Low
Lasting pain 4 26.84 Quite Low
depression 11 24.16 Low Low
withdrawal 19 16.96 Low Low
imagery 7 10.32 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 26 99.04 Very High Very High Very High
Inflammatory Pain 28 95.72 Very High Very High Very High
Nociception 10 54.88 Quite High
Hypersensitivity 16 35.88 Quite Low
Pain 7 26.84 Quite Low
Depression 11 24.16 Low Low
Syndrome 1 10.00 Low Low
Sleep Disorders 1 6.76 Low Low
Stress 4 5.00 Very Low Very Low Very Low
Togavirus Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is very likely that peripheral inflammatory insult does not alter translation of GluR1 and GluR2 genes and/or degradation of their proteins in dorsal horn neurons.
Protein_catabolism (degradation) of GluR2 in neurons associated with inflammation and dorsal horn neuron
1) Confidence 0.70 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.47 Pain Relevance 0.58
These results could be interpreted to suggest that newly synthesized GluR2 is rapidly targeted to the cell surface and there is a corresponding increase in degradation of intracellular GluR2 to maintain balance.
Protein_catabolism (degradation) of GluR2
2) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659165 Disease Relevance 0 Pain Relevance 0

General Comments

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