INT259169

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 18
Disease Relevance 9.98
Pain Relevance 9.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Gria2) plasma membrane (Gria2) protein complex (Gria2)
Anatomy Link Frequency
amygdala 30
plasma 2
neurons 2
Gria2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 384 100.00 Very High Very High Very High
Spinal cord 42 100.00 Very High Very High Very High
Inflammation 52 99.98 Very High Very High Very High
Kinase C 2 99.98 Very High Very High Very High
Eae 58 98.88 Very High Very High Very High
Hippocampus 768 97.72 Very High Very High Very High
Dorsal horn neuron 26 97.66 Very High Very High Very High
long-term potentiation 274 94.24 High High
depression 64 91.68 High High
central sensitization 8 76.32 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 52 99.98 Very High Very High Very High
Stress 1200 99.66 Very High Very High Very High
Inflammatory Pain 56 98.88 Very High Very High Very High
Depression 64 91.68 High High
Cognitive Disorder 48 66.96 Quite High
Hypersensitivity 32 60.96 Quite High
Syndrome 2 58.60 Quite High
Decapitation 34 5.00 Very Low Very Low Very Low
Affective Disorder 32 5.00 Very Low Very Low Very Low
Nociception 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, Protein kinase C phosphorylation of GluR2 at Ser880 disrupts GluR2 binding to its synaptic anchoring protein ABP/GRIP and promotes GluR2 internalization in cultured hippocampal neurons [36,37].
Positive_regulation (promotes) of Phosphorylation (phosphorylation) of GluR2 in neurons associated with kinase c
1) Confidence 0.40 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.46 Pain Relevance 0.51
The molecular mechanisms by which GluR1 is inserted into plasma membrane and GluR2 is internalized into cytoplasm in dorsal horn neurons during the maintenance phase of persistent inflammatory pain are unclear, but they might be related to inflammation-induced spinal cord GluR1 and GluR2 phosphorylation.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of GluR2 in plasma associated with inflammation, eae, dorsal horn neuron and spinal cord
2) Confidence 0.32 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.39 Pain Relevance 0.49
In contrast, the increased phosphorylation of the Ser880-GluA2 residue in the mPFC that we observed suggests acute stress increases AMPAR internalization and facilitates the generation of LTD in that region.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of GluA2 associated with stress
3) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.62 Pain Relevance 0.37
Thirty minutes after the end of stress, changes in the phosphorylation sites of both GluA1 and GluA2 were found, with a decreased phosphorylation level at the Tyr876-GluA2 and Ser880-GluA2 sites in the amygdala (t (23)?
Positive_regulation (-) of Phosphorylation (phosphorylation) of GluA2 in amygdala associated with stress and amygdala
4) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.51 Pain Relevance 0.49
Thirty minutes after the end of stress, changes in the phosphorylation sites of both GluA1 and GluA2 were found, with a decreased phosphorylation level at the Tyr876-GluA2 and Ser880-GluA2 sites in the amygdala (t (23)?
Positive_regulation (-) of Phosphorylation (phosphorylation) of GluA2 in amygdala associated with stress and amygdala
5) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.52 Pain Relevance 0.49
Thirty minutes after the end of stress, changes in the phosphorylation sites of both GluA1 and GluA2 were found, with a decreased phosphorylation level at the Tyr876-GluA2 and Ser880-GluA2 sites in the amygdala (t (23)?
Positive_regulation (-) of Phosphorylation (phosphorylation) of GluA2 in amygdala associated with stress and amygdala
6) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.52 Pain Relevance 0.49
Thirty minutes after the end of stress, changes in the phosphorylation sites of both GluA1 and GluA2 were found, with a decreased phosphorylation level at the Tyr876-GluA2 and Ser880-GluA2 sites in the amygdala (t (23)?
Positive_regulation (-) of Phosphorylation (phosphorylation) of GluA2 in amygdala associated with stress and amygdala
7) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.51 Pain Relevance 0.48
Thirty minutes after the end of stress, changes in the phosphorylation sites of both GluA1 and GluA2 were found, with a decreased phosphorylation level at the Tyr876-GluA2 and Ser880-GluA2 sites in the amygdala (t (23)?
Positive_regulation (-) of Phosphorylation (phosphorylation) of GluA2 in amygdala associated with stress and amygdala
8) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.51 Pain Relevance 0.48
Thirty minutes after the end of stress, changes in the phosphorylation sites of both GluA1 and GluA2 were found, with a decreased phosphorylation level at the Tyr876-GluA2 and Ser880-GluA2 sites in the amygdala (t (23)?
Positive_regulation (-) of Phosphorylation (phosphorylation) of GluA2 in amygdala associated with stress and amygdala
9) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.52 Pain Relevance 0.49
Stress also modulated the GluA2 subunit with a decrease in the phosphorylation of both Tyr876-GluA2 and Ser880-GluA2 residues in the amygdala, and an increase in the phosphorylation of Ser880-GluA2 in the mPFC.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of GluA2 in amygdala associated with stress and amygdala
10) Confidence 0.23 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2999558 Disease Relevance 0.78 Pain Relevance 0.72
Thirty minutes after the end of stress, changes in the phosphorylation sites of both GluA1 and GluA2 were found, with a decreased phosphorylation level at the Tyr876-GluA2 and Ser880-GluA2 sites in the amygdala (t (23)?
Positive_regulation (-) of Phosphorylation (phosphorylation) of GluA2 in amygdala associated with stress and amygdala
11) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.52 Pain Relevance 0.49
Stress also modulated the GluA2 subunit with a decrease in the phosphorylation of both Tyr876-GluA2 and Ser880-GluA2 residues in the amygdala, and an increase in the phosphorylation of Ser880-GluA2 in the mPFC.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of GluA2 in amygdala associated with stress and amygdala
12) Confidence 0.23 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2999558 Disease Relevance 0.78 Pain Relevance 0.72
Thirty minutes after the end of stress, changes in the phosphorylation sites of both GluA1 and GluA2 were found, with a decreased phosphorylation level at the Tyr876-GluA2 and Ser880-GluA2 sites in the amygdala (t (23)?
Positive_regulation (-) of Phosphorylation (phosphorylation) of GluA2 in amygdala associated with stress and amygdala
13) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.51 Pain Relevance 0.48
Thirty minutes after the end of stress, changes in the phosphorylation sites of both GluA1 and GluA2 were found, with a decreased phosphorylation level at the Tyr876-GluA2 and Ser880-GluA2 sites in the amygdala (t (23)?
Positive_regulation (-) of Phosphorylation (phosphorylation) of GluA2 in amygdala associated with stress and amygdala
14) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.52 Pain Relevance 0.49
Thirty minutes after the end of stress, changes in the phosphorylation sites of both GluA1 and GluA2 were found, with a decreased phosphorylation level at the Tyr876-GluA2 and Ser880-GluA2 sites in the amygdala (t (23)?
Positive_regulation (-) of Phosphorylation (phosphorylation) of GluA2 in amygdala associated with stress and amygdala
15) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.52 Pain Relevance 0.49
Thirty minutes after the end of stress, changes in the phosphorylation sites of both GluA1 and GluA2 were found, with a decreased phosphorylation level at the Tyr876-GluA2 and Ser880-GluA2 sites in the amygdala (t (23)?
Positive_regulation (-) of Phosphorylation (phosphorylation) of GluA2 in amygdala associated with stress and amygdala
16) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.51 Pain Relevance 0.48
Thirty minutes after the end of stress, changes in the phosphorylation sites of both GluA1 and GluA2 were found, with a decreased phosphorylation level at the Tyr876-GluA2 and Ser880-GluA2 sites in the amygdala (t (23)?
Positive_regulation (-) of Phosphorylation (phosphorylation) of GluA2 in amygdala associated with stress and amygdala
17) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.51 Pain Relevance 0.48
Stress also modulated the GluA2 subunit with a decrease in the phosphorylation of both Tyr876-GluA2 and Ser880-GluA2 residues in the amygdala, and an increase in the phosphorylation of Ser880-GluA2 in the mPFC.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of GluA2 in amygdala associated with stress and amygdala
18) Confidence 0.23 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2999558 Disease Relevance 0.77 Pain Relevance 0.70

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