INT259181

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.40
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pdpk1, Gria1) plasma membrane (Pdpk1, Gria1) endoplasmic reticulum (Gria1)
protein complex (Gria1) cytoplasm (Pdpk1) nucleus (Pdpk1)
Anatomy Link Frequency
spinal 3
Pdpk1 (Rattus norvegicus)
Gria1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 21 98.64 Very High Very High Very High
Inflammation 26 97.84 Very High Very High Very High
long-term potentiation 1 97.64 Very High Very High Very High
Eae 29 95.64 Very High Very High Very High
Dorsal horn neuron 13 93.20 High High
Kinase C 1 83.36 Quite High
Dorsal horn 21 63.60 Quite High
central sensitization 4 49.28 Quite Low
antagonist 27 5.00 Very Low Very Low Very Low
withdrawal 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 26 97.84 Very High Very High Very High
Inflammatory Pain 28 95.64 Very High Very High Very High
Syndrome 1 56.48 Quite High
Hypersensitivity 16 33.92 Quite Low
Nociception 10 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
Neuropathic Pain 2 5.00 Very Low Very Low Very Low
Hyperalgesia 1 5.00 Very Low Very Low Very Low
Sleep Disorders 1 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Protein kinase A phosphorylation of GluR1 Ser845 promotes the surface-expression of GluR1 in cultured hippocampal neurons during activity-dependent long-term potentiation [35] and might also be responsible for spinal GluR1 membrane insertion in vivo following CFA-induced inflammation.
Phosphorylation (phosphorylation) of Protein kinase in spinal Positive_regulation (promotes) of Gene_expression (expression) of GluR1 in spinal associated with inflammation and long-term potentiation
1) Confidence 0.02 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.40 Pain Relevance 0.49

General Comments

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