INT259183

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.39
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Gria1, Gria2) plasma membrane (Gria1, Gria2) protein complex (Gria1, Gria2)
cytosol (Gria1)
Anatomy Link Frequency
plasma 2
Gria1 (Rattus norvegicus)
Gria2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 21 100.00 Very High Very High Very High
Inflammation 26 99.98 Very High Very High Very High
Eae 29 98.88 Very High Very High Very High
Dorsal horn neuron 13 97.66 Very High Very High Very High
long-term potentiation 1 88.00 High High
Kinase C 1 76.08 Quite High
Dorsal horn 21 65.72 Quite High
central sensitization 4 42.00 Quite Low
antagonist 27 5.00 Very Low Very Low Very Low
withdrawal 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 26 99.98 Very High Very High Very High
Inflammatory Pain 28 98.88 Very High Very High Very High
Syndrome 1 58.60 Quite High
Hypersensitivity 16 26.64 Quite Low
Nociception 10 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
Neuropathic Pain 2 5.00 Very Low Very Low Very Low
Hyperalgesia 1 5.00 Very Low Very Low Very Low
Sleep Disorders 1 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The molecular mechanisms by which GluR1 is inserted into plasma membrane and GluR2 is internalized into cytoplasm in dorsal horn neurons during the maintenance phase of persistent inflammatory pain are unclear, but they might be related to inflammation-induced spinal cord GluR1 and GluR2 phosphorylation.
GluR1 Positive_regulation (induced) of Phosphorylation (phosphorylation) of GluR2 in plasma associated with inflammation, eae, dorsal horn neuron and spinal cord
1) Confidence 0.30 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.39 Pain Relevance 0.49

General Comments

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