INT259184

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.28
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Gria2, Gria1) plasma membrane (Gria2, Gria1) protein complex (Gria2, Gria1)
cytosol (Gria1)
Anatomy Link Frequency
neurons 1
Gria2 (Rattus norvegicus)
Gria1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn neuron 13 99.84 Very High Very High Very High
Dorsal horn 21 91.32 High High
Glutamate receptor 23 86.56 High High
Eae 29 83.80 Quite High
Inflammation 26 53.84 Quite High
Spinal cord 22 52.16 Quite High
long-term potentiation 1 36.72 Quite Low
Kinase C 1 24.80 Low Low
antagonist 36 5.00 Very Low Very Low Very Low
Glutamate 31 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 1 84.20 Quite High
Inflammatory Pain 28 83.80 Quite High
INFLAMMATION 26 53.84 Quite High
Hypersensitivity 16 5.00 Very Low Very Low Very Low
Nociception 10 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
Disease 7 5.00 Very Low Very Low Very Low
Intellectual Impairment 3 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Neuropathic Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is possible that GluR1 membrane insertion and GluR2 internalization in dorsal horn neurons are too minimal at 2 h post-CFA injection to be detected by this approach.
GluR2 Binding (internalization) of GluR1 in neurons associated with dorsal horn neuron
1) Confidence 0.26 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.28 Pain Relevance 0.43
However, electrophysiological recordings from GluN2 subunits carrying mutation in the NTD suggest a model in which NTDs of GluN1 and GluN2 heterodimerize [134].
GluN2 Binding (heterodimerize) of GluN1
2) Confidence 0.06 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0 Pain Relevance 0.11

General Comments

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