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Context Info
Confidence 0.24
First Reported 1979
Last Reported 1990
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.34
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (REN) extracellular space (REN) extracellular region (REN)
intracellular (REN) response to stress (REN)
Anatomy Link Frequency
plasma 6
REN (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 7 99.24 Very High Very High Very High
Clonidine 9 99.10 Very High Very High Very High
anesthesia 2 99.00 Very High Very High Very High
corticosteroid 5 66.80 Quite High
antagonist 2 63.84 Quite High
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 2 100.00 Very High Very High Very High
Bradycardia 1 100.00 Very High Very High Very High
Natriuresis 2 75.00 Quite High
Cv Unclassified Under Development 1 25.00 Low Low
Bartter Syndrome 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intravenous infusion of somatostatin in mongrel dogs caused a significant decrease in the peripheral plasma renin activity (PRA) enhanced by pentobarbital sodium anesthesia or furosemide treatment.
Positive_regulation (enhanced) of Negative_regulation (decrease) of renin in plasma associated with anesthesia and somatostatin
1) Confidence 0.24 Published 1979 Journal Endocrinol. Jpn. Section Abstract Doc Link 477626 Disease Relevance 0 Pain Relevance 0.30
Ang II-induced sodium retention and stimulation of aldosterone production were attenuated, and renin suppression was enhanced in dogs having the largest changes in plasma ANF in response to converting enzyme inhibition or Ang II.
Positive_regulation (enhanced) of Negative_regulation (suppression) of renin in plasma
2) Confidence 0.03 Published 1990 Journal Circ. Res. Section Abstract Doc Link 2144484 Disease Relevance 0.14 Pain Relevance 0.03
Injection of clonidine (30 micrograms/kg i.v.) produced an initial increase in arterial pressure followed by hypotension, decreased heart rate, increased right atrial pressure and decreased plasma renin activity.
Positive_regulation (increase) of Negative_regulation (decreased) of plasma renin in plasma associated with pressure volume 2 under development, bradycardia and clonidine
3) Confidence 0.00 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6323682 Disease Relevance 0.20 Pain Relevance 0.30

General Comments

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