INT259209

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Context Info
Confidence 0.03
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 4.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Glul, Flna) mitochondrion (Glul) lyase activity (Glul)
Golgi apparatus (Glul) intracellular (Glul) protein complex (Glul)
Glul (Rattus norvegicus)
Flna (Rattus norvegicus)
Pain Link Frequency Relevance Heat
mu opioid receptor 291 100.00 Very High Very High Very High
Morphine 228 97.44 Very High Very High Very High
narcan 201 95.04 Very High Very High Very High
Opioid 126 94.96 High High
opiate 12 90.92 High High
addiction 51 89.44 High High
tolerance 39 88.96 High High
antagonist 15 69.76 Quite High
Analgesic 9 51.28 Quite High
Oxycodone 9 8.56 Low Low
Disease Link Frequency Relevance Heat
Opiate Addiction 12 5.00 Very Low Very Low Very Low
Drug Dependence 6 5.00 Very Low Very Low Very Low
Bordatella Infection 3 5.00 Very Low Very Low Very Low
Decapitation 3 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We theorized that a particular FLNA–MOR interaction enables MOR to release from the signaling complex to couple to Gs upon subsequent receptor stimulation.
Gs Binding (couple) of FLNA associated with mu opioid receptor
1) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.44
The control peptide, FLNA2561–2565 with one mid-point lysine-to-alanine substitution (VAAGL), did not prevent the MOR–Gs coupling, but mildly preserved Go coupling at 15 minutes.
Gs Binding (coupling) of FLNA2561 associated with mu opioid receptor
2) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.49
In the present study, we showed the pentapeptide FLNA2561–2565 itself may act as a decoy for MOR to prevent the MOR–FLNA interaction and subsequent Gs coupling by MOR.
Gs Binding (interaction) of FLNA associated with mu opioid receptor
3) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.27

General Comments

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