INT259214

Context Info Confidence 0.01 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 2.64

signal transducer activity (Oprm1, Flna, Flna) plasma membrane (Oprm1, Flna, Flna) cytoplasm (Flna, Flna) cytosol (Flna, Flna) nucleus (Flna, Flna) transcription factor binding (Flna, Flna)

Oprm1 (Mus musculus) Flna (Rattus norvegicus) Flna (Rattus norvegicus)

Pain Link Frequency Relevance Heat mu opioid receptor 194 100.00 Opioid 84 97.64 narcan 134 96.32 opiate 8 93.60 addiction 34 92.12 tolerance 26 91.64 Morphine 152 87.52 antagonist 10 47.20 Analgesic 6 28.72 analgesia 6 5.00

Disease Link Frequency Relevance Heat Opiate Addiction 8 5.00 Drug Dependence 4 5.00 Bordatella Infection 2 5.00 Decapitation 2 5.00 Injury 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the present study, we showed the pentapeptide FLNA2561–2565 itself may act as a decoy for MOR to prevent the MOR–FLNA interaction and subsequent Gs coupling by MOR.

MOR Negative_regulation (prevent) of FLNA Binding (interaction) of FLNA2561 associated with mu opioid receptor

1) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.29

In the present study, we showed the pentapeptide FLNA2561–2565 itself may act as a decoy for MOR to prevent the MOR–FLNA interaction and subsequent Gs coupling by MOR.

MOR Negative_regulation (prevent) of FLNA Binding (interaction) of FLNA2561 associated with mu opioid receptor

2) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.35

General Comments

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