INT259214

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 2.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Oprm1, Flna, Flna) plasma membrane (Oprm1, Flna, Flna) cytoplasm (Flna, Flna)
cytosol (Flna, Flna) nucleus (Flna, Flna) transcription factor binding (Flna, Flna)
Oprm1 (Mus musculus)
Flna (Rattus norvegicus)
Flna (Rattus norvegicus)
Pain Link Frequency Relevance Heat
mu opioid receptor 194 100.00 Very High Very High Very High
Opioid 84 97.64 Very High Very High Very High
narcan 134 96.32 Very High Very High Very High
opiate 8 93.60 High High
addiction 34 92.12 High High
tolerance 26 91.64 High High
Morphine 152 87.52 High High
antagonist 10 47.20 Quite Low
Analgesic 6 28.72 Quite Low
analgesia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Opiate Addiction 8 5.00 Very Low Very Low Very Low
Drug Dependence 4 5.00 Very Low Very Low Very Low
Bordatella Infection 2 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we showed the pentapeptide FLNA2561–2565 itself may act as a decoy for MOR to prevent the MOR–FLNA interaction and subsequent Gs coupling by MOR.
MOR Negative_regulation (prevent) of FLNA Binding (interaction) of FLNA2561 associated with mu opioid receptor
1) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.29
In the present study, we showed the pentapeptide FLNA2561–2565 itself may act as a decoy for MOR to prevent the MOR–FLNA interaction and subsequent Gs coupling by MOR.
MOR Negative_regulation (prevent) of FLNA Binding (interaction) of FLNA2561 associated with mu opioid receptor
2) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.35

General Comments

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