INT259224

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Context Info
Confidence 0.23
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.15
Pain Relevance 2.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Flna) plasma membrane (Flna) nucleus (Flna)
transcription factor binding (Flna) biological_process (Flna) cytoplasm (Flna)
Flna (Rattus norvegicus)
Pain Link Frequency Relevance Heat
mu opioid receptor 194 100.00 Very High Very High Very High
Morphine 152 100.00 Very High Very High Very High
narcan 134 100.00 Very High Very High Very High
tolerance 26 98.80 Very High Very High Very High
withdrawal 6 96.04 Very High Very High Very High
addiction 34 95.48 Very High Very High Very High
antagonist 10 82.40 Quite High
Opioid 84 81.96 Quite High
Analgesic 6 63.92 Quite High
opiate 8 57.28 Quite High
Disease Link Frequency Relevance Heat
Drug Dependence 4 95.48 Very High Very High Very High
Opiate Addiction 8 8.88 Low Low
Bordatella Infection 2 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, the equivalent blockade of Gs coupling and pS133CREB by the NLX and NTX pentapeptide binding site on FLNA further elucidates the mechanism of action of ultra-low-dose NLX and NTX in their varied effects.
Negative_regulation (blockade) of FLNA associated with narcan
1) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0.15 Pain Relevance 1.05
In this prior study, FLNA peptides presumably bound to NLX, blocking its prevention of the morphine-induced MOR–Gs coupling by preventing it from binding full-length FLNA in the tissues.
Negative_regulation (prevention) of FLNA associated with mu opioid receptor, narcan and morphine
2) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.47

General Comments

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