INT259228

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Context Info
Confidence 0.00
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.08
Pain Relevance 7.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Glul) lyase activity (Glul) Golgi apparatus (Glul)
intracellular (Glul) protein complex (Glul) ligase activity (Glul)
Oprm1 (Mus musculus)
Glul (Rattus norvegicus)
Pain Link Frequency Relevance Heat
mu opioid receptor 485 100.00 Very High Very High Very High
Morphine 380 99.96 Very High Very High Very High
narcan 335 98.04 Very High Very High Very High
tolerance 65 93.20 High High
addiction 85 92.76 High High
opiate 20 92.08 High High
Opioid 210 90.68 High High
withdrawal 15 85.16 High High
Analgesic 15 79.04 Quite High
antagonist 25 69.56 Quite High
Disease Link Frequency Relevance Heat
Drug Dependence 10 84.60 Quite High
Bordatella Infection 5 33.96 Quite Low
Opiate Addiction 20 5.00 Very Low Very Low Very Low
Decapitation 5 5.00 Very Low Very Low Very Low
Injury 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We theorized that a particular FLNA–MOR interaction enables MOR to release from the signaling complex to couple to Gs upon subsequent receptor stimulation.
MOR Binding (couple) of Gs associated with mu opioid receptor
1) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.44
We theorized that a particular FLNA–MOR interaction enables MOR to release from the signaling complex to couple to Gs upon subsequent receptor stimulation.
MOR Binding (couple) of Gs associated with mu opioid receptor
2) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.37
The control peptide, FLNA2561–2565 with one mid-point lysine-to-alanine substitution (VAAGL), did not prevent the MOR–Gs coupling, but mildly preserved Go coupling at 15 minutes.
MOR Binding (coupling) of Gs associated with mu opioid receptor
3) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.46
Instead we propose that with even this brief period of continued stimulation following high-dose morphine, MOR initially couples to Gs instead of Gi/o but is able to recover.
MOR Binding (couples) of Gs associated with mu opioid receptor and morphine
4) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 2.02
These data strengthen our hypothesis that a particular MOR–FLNA interaction allows MOR to couple to Gs and that disrupting this interaction, either by NLX/NTX binding to FLNA or via a FLNA peptide binding to MOR and/or FLNA, can prevent the altered coupling and attenuate tolerance, dependence and addictive properties associated with opioid drugs.



MOR Binding (couple) of Gs associated with addiction, tolerance, narcan, mu opioid receptor and opioid
5) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0.08 Pain Relevance 0.93

General Comments

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