INT259230

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Context Info
Confidence 0.02
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 4.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Oprm1, Flna) plasma membrane (Oprm1, Flna) cytoplasm (Flna)
cytosol (Flna) signal transduction (Oprm1) nucleus (Flna)
Oprm1 (Mus musculus)
Flna (Rattus norvegicus)
Pain Link Frequency Relevance Heat
mu opioid receptor 291 100.00 Very High Very High Very High
narcan 201 99.80 Very High Very High Very High
tolerance 39 98.00 Very High Very High Very High
Morphine 228 97.60 Very High Very High Very High
addiction 51 97.56 Very High Very High Very High
opiate 12 95.96 Very High Very High Very High
Opioid 126 95.60 Very High Very High Very High
opioid receptor 3 61.40 Quite High
antagonist 15 59.52 Quite High
analgesia 9 51.96 Quite High
Disease Link Frequency Relevance Heat
Opiate Addiction 12 5.00 Very Low Very Low Very Low
Drug Dependence 6 5.00 Very Low Very Low Very Low
Bordatella Infection 3 5.00 Very Low Very Low Very Low
Decapitation 3 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also implicating FLNA in desensitization, our recent organotypic striatal slice culture data showed that potentially disrupting the MOR–FLNA interaction via NLX's high-affinity binding to FLNA blocks the chronic morphine-induced G protein coupling switch by MOR [9].
Negative_regulation (disrupting) of MOR Binding (interaction) of FLNA associated with narcan, mu opioid receptor and morphine
1) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.49
In the present study, we showed the pentapeptide FLNA2561–2565 itself may act as a decoy for MOR to prevent the MOR–FLNA interaction and subsequent Gs coupling by MOR.
Negative_regulation (prevent) of MOR Binding (interaction) of FLNA associated with mu opioid receptor
2) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.33
While blocking the MOR–FLNA association, at least via ultra-low-dose NLX/NTX, diminishes tolerance, dependence and the rewarding effects of opiates, preserving or enhancing MOR's association with spinophilin appears to similarly modify these opioid effects.
Negative_regulation (blocking) of MOR Binding (association) of FLNA associated with addiction, tolerance, narcan, mu opioid receptor, opiate and opioid
3) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.32

General Comments

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