INT259231

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 2.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprm1, Ppp1r9b) cell differentiation (Ppp1r9b) nucleoplasm (Ppp1r9b)
cytoplasm (Ppp1r9b) signal transducer activity (Oprm1) signal transduction (Oprm1)
Oprm1 (Mus musculus)
Ppp1r9b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
mu opioid receptor 194 100.00 Very High Very High Very High
opiate 8 99.48 Very High Very High Very High
addiction 34 98.74 Very High Very High Very High
Opioid 84 98.60 Very High Very High Very High
tolerance 26 98.50 Very High Very High Very High
narcan 134 97.98 Very High Very High Very High
Morphine 152 82.56 Quite High
antagonist 10 63.92 Quite High
Analgesic 6 45.44 Quite Low
analgesia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Opiate Addiction 8 5.00 Very Low Very Low Very Low
Drug Dependence 4 5.00 Very Low Very Low Very Low
Bordatella Infection 2 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to FLNA, MOR has recently been shown to interact with another scaffolding protein, spinophilin (Charlton et al., 2008).
MOR Binding (interact) of spinophilin associated with mu opioid receptor
1) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.33
While blocking the MOR–FLNA association, at least via ultra-low-dose NLX/NTX, diminishes tolerance, dependence and the rewarding effects of opiates, preserving or enhancing MOR's association with spinophilin appears to similarly modify these opioid effects.
MOR Binding (association) of spinophilin associated with addiction, tolerance, narcan, mu opioid receptor, opiate and opioid
2) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.34

General Comments

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