INT259233

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Context Info
Confidence 0.03
First Reported 2009
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 21
Disease Relevance 0.25
Pain Relevance 25.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Oprm1, Flna) plasma membrane (Oprm1, Flna) cytoplasm (Flna)
cytosol (Flna) signal transduction (Oprm1) nucleus (Flna)
Anatomy Link Frequency
brain 1
Oprm1 (Mus musculus)
Flna (Rattus norvegicus)
Pain Link Frequency Relevance Heat
mu opioid receptor 2037 100.00 Very High Very High Very High
narcan 1407 100.00 Very High Very High Very High
Morphine 1596 99.20 Very High Very High Very High
tolerance 273 98.00 Very High Very High Very High
Opioid 882 97.64 Very High Very High Very High
addiction 357 97.56 Very High Very High Very High
opiate 84 95.96 Very High Very High Very High
withdrawal 63 81.12 Quite High
antagonist 105 76.24 Quite High
opioid receptor 21 69.68 Quite High
Disease Link Frequency Relevance Heat
Bordatella Infection 21 90.96 High High
Injury 21 80.64 Quite High
Drug Dependence 42 80.56 Quite High
Decapitation 21 36.36 Quite Low
Opiate Addiction 84 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to FLNA, MOR has recently been shown to interact with another scaffolding protein, spinophilin (Charlton et al., 2008).
MOR Binding (interact) of FLNA associated with mu opioid receptor
1) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.25
To determine whether NLX's effect may be mimicked by the site on FLNA that interacts with MOR, brain slices were incubated with morphine plus 10 µM VAKGL (FLNA2561–2565) or control pentapeptide, VAAGL.
MOR Binding (interacts) of FLNA in brain associated with mu opioid receptor, narcan and morphine
2) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0.08 Pain Relevance 1.01
We theorized that a particular FLNA–MOR interaction enables MOR to release from the signaling complex to couple to Gs upon subsequent receptor stimulation.
MOR Binding (couple) of FLNA associated with mu opioid receptor
3) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.44
To elucidate whether the pentapeptide FLNA fragment VAKGL functions as a MOR decoy by binding to MOR or interacts with full-length FLNA, we utilized a cell-free system.
MOR Binding (binding) of FLNA associated with mu opioid receptor
4) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 0.42
These data strengthen our hypothesis that a particular MOR–FLNA interaction allows MOR to couple to Gs and that disrupting this interaction, either by NLX/NTX binding to FLNA or via a FLNA peptide binding to MOR and/or FLNA, can prevent the altered coupling and attenuate tolerance, dependence and addictive properties associated with opioid drugs.



MOR Binding (binding) of FLNA associated with addiction, tolerance, narcan, mu opioid receptor and opioid
5) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0.08 Pain Relevance 0.88
In the present study, we showed the pentapeptide FLNA2561–2565 itself may act as a decoy for MOR to prevent the MOR–FLNA interaction and subsequent Gs coupling by MOR.
MOR Binding (interaction) of FLNA associated with mu opioid receptor
6) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.30
Onoprishvili et al. [12] first showed FLNA to interact with MOR and suggested a role in MOR downregulation and desensitization.
MOR Binding (interact) of FLNA associated with mu opioid receptor
7) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.59
Also implicating FLNA in desensitization, our recent organotypic striatal slice culture data showed that potentially disrupting the MOR–FLNA interaction via NLX's high-affinity binding to FLNA blocks the chronic morphine-induced G protein coupling switch by MOR [9].
MOR Binding (interaction) of FLNA associated with narcan, mu opioid receptor and morphine
8) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.46
Also implicating FLNA in desensitization, our recent organotypic striatal slice culture data showed that potentially disrupting the MOR–FLNA interaction via NLX's high-affinity binding to FLNA blocks the chronic morphine-induced G protein coupling switch by MOR [9].
MOR Binding (interaction) of FLNA associated with narcan, mu opioid receptor and morphine
9) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.48
Also implicating FLNA in desensitization, our recent organotypic striatal slice culture data showed that potentially disrupting the MOR–FLNA interaction via NLX's high-affinity binding to FLNA blocks the chronic morphine-induced G protein coupling switch by MOR [9].
MOR Binding (binding) of FLNA associated with narcan, mu opioid receptor and morphine
10) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.48
We propose that acute, robust stimulation of MOR causes an interaction with FLNA that allows an initially transient MOR–Gs coupling, which recovers with receptor recycling but persists when MOR stimulation is repeated or prolonged.
MOR Binding (interaction) of FLNA associated with mu opioid receptor
11) Confidence 0.02 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.23
These data led us to postulate that the interaction between MOR and FLNA, first demonstrated by Onoprishvili et al. (2003), was critical to the G protein coupling switch.
MOR Binding (interaction) of FLNA associated with mu opioid receptor
12) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.34
In the present study, we showed the pentapeptide FLNA2561–2565 itself may act as a decoy for MOR to prevent the MOR–FLNA interaction and subsequent Gs coupling by MOR.
MOR Binding (interaction) of FLNA2561 associated with mu opioid receptor
13) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.29
Both MOR and FLNA bound VAKGL-coated plates (Fig. 7), suggesting that the VAKGL pentapeptide may disrupt the MOR–FLNA interaction by binding to MOR as a decoy for FLNA and/or by binding to FLNA itself.


MOR Binding (interaction) of FLNA associated with mu opioid receptor
14) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0.09 Pain Relevance 1.04
While blocking the MOR–FLNA association, at least via ultra-low-dose NLX/NTX, diminishes tolerance, dependence and the rewarding effects of opiates, preserving or enhancing MOR's association with spinophilin appears to similarly modify these opioid effects.
MOR Binding (association) of FLNA associated with addiction, tolerance, narcan, mu opioid receptor, opiate and opioid
15) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.32
While blocking the MOR–FLNA association, at least via ultra-low-dose NLX/NTX, diminishes tolerance, dependence and the rewarding effects of opiates, preserving or enhancing MOR's association with spinophilin appears to similarly modify these opioid effects.
MOR Binding (association) of FLNA associated with addiction, tolerance, narcan, mu opioid receptor, opiate and opioid
16) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.32
In the present study, we showed the pentapeptide FLNA2561–2565 itself may act as a decoy for MOR to prevent the MOR–FLNA interaction and subsequent Gs coupling by MOR.
MOR Binding (interaction) of FLNA associated with mu opioid receptor
17) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.24
In the present study, we showed the pentapeptide FLNA2561–2565 itself may act as a decoy for MOR to prevent the MOR–FLNA interaction and subsequent Gs coupling by MOR.
MOR Binding (interaction) of FLNA associated with mu opioid receptor
18) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.24
NLX and NTX presumably prevent the MOR–FLNA interaction by binding to their VAKGL binding site on FLNA, and this binding site on FLNA does appear be the approximate site on this protein that interacts with MOR.
MOR Neg (prevent) Binding (interaction) of FLNA associated with mu opioid receptor and narcan
19) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.22
The demonstration that both purified MOR and FLNA proteins bind to VAKGL suggests that the VAKGL pentapeptide can similarly prevent the MOR–FLNA interaction but by binding to either protein.
MOR Binding (interaction) of FLNA associated with mu opioid receptor
20) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.12

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