INT259408

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.01
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Atp6v0d2) transport (Atp6v0d2)
Anatomy Link Frequency
osteoclasts 2
stalks 1
Atp6v0d2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 72 88.24 High High
Arthritis 75 87.04 High High
agonist 40 85.28 High High
cytokine 14 60.72 Quite High
IPN 3 57.00 Quite High
Pain 5 17.84 Low Low
metalloproteinase 1 5.04 Very Low Very Low Very Low
rheumatoid arthritis 16 5.00 Very Low Very Low Very Low
antagonist 8 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 4 99.68 Very High Very High Very High
Osteopetrosis 74 99.28 Very High Very High Very High
Hypercalcemia 17 97.72 Very High Very High Very High
Pressure And Volume Under Development 18 93.84 High High
INFLAMMATION 60 88.24 High High
Arthritis 107 87.04 High High
Bone Cancer 4 76.00 Quite High
Arthropathy 10 66.76 Quite High
Leukoencephalopathies 2 56.00 Quite High
Disease 51 52.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression and purification of a recombinant fragment polypeptide of E. histolytica V-ATPase subunit B in Escherichia coli
Gene_expression (Expression) of V-ATPase
1) Confidence 0.09 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2629482 Disease Relevance 0 Pain Relevance 0.06
Some cells presented the EhV-ATPase B subunit in two EhkOs located in different planes (Fig. 4a, c, arrows).
Gene_expression (presented) of EhV-ATPase
2) Confidence 0.09 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2629482 Disease Relevance 0 Pain Relevance 0
Homozygous mutations in the genes encoding the a3 subunit of V-ATPase (TCIRG1) and the CLCN-7 produce severe malignant osteopetrosis phenotypes in both humans and mice [37-40].
Gene_expression (produce) of V-ATPase associated with osteopetrosis and malignant neoplastic disease
3) Confidence 0.07 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2654865 Disease Relevance 0.73 Pain Relevance 0
A relationship of two G molecules per one E molecule was assumed, however recent data support that in V-ATPase, G and E subunits are present in more than one copy and thus two peripheral stalks connecting V1 to V0 could exist [41].
Gene_expression (present) of V-ATPase in stalks
4) Confidence 0.04 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2629482 Disease Relevance 0 Pain Relevance 0
We also demonstrate that MDL-1 activation increases the expression of NFATc1 and ATPV0D2, which control cell fusion (Lee et al., 2006), as well as regulating bone resorption via TRAP and cathepsin K in osteoclasts (Takayanagi, 2005a).
Gene_expression (expression) of ATPV0D2 in osteoclasts associated with hypercalcemia
5) Confidence 0.02 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 1.00 Pain Relevance 0.28
The apparent regulation of the TRAP, RANKL, ATPV0D2, and MMP9 expression after anti–MDL-1 treatment suggests MDL-1 receptor activation may promote osteoclast development and function.
Gene_expression (expression) of ATPV0D2 in osteoclast
6) Confidence 0.02 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.28 Pain Relevance 0.21

General Comments

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